Label-Free Fluorescent Aptasensor Based on a Graphene Oxide Self-Assembled Probe for the Determination of Adenosine Triphosphate

Aptamers used for biosensors and targeted therapy

“…In addition, false-positive signals can be avoided due to the high transfer efficiency between GO and the SYBR Green I-DNA duplex structure ( Fig. 7 B) [ 133 ]. Overall, the GO-based aptasensor has the merits of high sensitivity, quick response, good reproducibility, and stability, making it a promising candidate for environmental monitoring, medical diagnostics, and food safety assays.…”

Ultrasensitive fluorescent aptasensor for MUC1 detection based on deoxyribonuclease I-aided target recycling signal amplification

“… 41 More importantly, GO can improve their stability in the biological environments, due to its protection capacity for biomolecules binded to its surface from enzymatic cleavage. 42 Consequently, GO, as a superb nanomaterial, would be easily used in biosensors for biochemical analysis. On the other hand, to overcome these limitations, signal amplification strategies, enzyme-aided signal amplification have recently been developed to achieve the sensitive detection of biomolecules, including endonuclease, deoxyribonuclease I (DNase I), exdonuclease and DNA polymerase.…”

A Graphene Oxide–Based Sensing Platform for the Determination of Methicillin-Resistant Staphylococcus aureus Based on Strand-Displacement Polymerization Recycling and Synchronous Fluorescent Signal Amplification

“…Using GO-based sensing platforms, some biosensors have already been designed to detect ATP, thrombin, and other small heavy metal ions. [25][26][27] However, few studies have focused on the development of such sensors for detecting drug-resistant strains of bacteria. In order to detect such strains, there is a need to construct platforms based on GO that are sensitive and selective.…”