Label-free electrochemical immunosensor based on gold nanoparticle/polyethyleneimine/reduced graphene oxide nanocomposites for the ultrasensitive detection of cancer biomarker matrix metalloproteinase-1

Abstract

Matrix metalloproteinase-1 (MMP-1) is associated with many types of cancers, including oral, colorectal, and brain cancers. This paper describes the fabrication of an MMP-1 immunosensor based on a gold nanoparticle/polyethyleneimine/reduced...

Detecting the PEX Like Domain of Matrix Metalloproteinase-14 (MMP-14) with Therapeutic Conjugated CNTs

“…Indeed, the 2D nanostructured immunosensor showed improvements and presented range of detection from 10 pg.mL −1 to 75 ng⋅mL −1 and LOD of 7 pg⋅mL −1 . 2D graphene structures were also employed to detect MMP-1 protein in an immunosensor based on a gold nanoparticle, polyethyleneimine and reduced graphene oxide [ 75 ]. The system showed great performance in different body fluids with range of detection from 1 ng⋅mL −1 to 50 ng⋅ml −1 and LOD of 0.2 ng⋅ml −1 .…”

Construction of Sr@Mn3O4/GO nanocomposite: a synergistic electrocatalyst for nitrofurantoin detection in biological and environmental samples

“…41 There are many oxygen functional groups available on the edges and surfaces of the GO including C–O–C, –COOH, and –OH functional groups which can produce accessible reactive sites for the coupling and nucleation of various materials and also address the issue of inadequate hydrophilicity. 42 The dispersing and stabilizing properties can be improved by GO support with different nanostructured materials. 18 In addition, GO is a layered structure that can be exfoliated or intercalated by tiny molecules.…”

Role of Defects of Carbon Nanomaterials in the Detection of Ovarian Cancer Cells in Label-Free Electrochemical Immunosensors

“…Gold nanoparticles (AuNPs) have received more attention in electrochemical and biosensor applications because of the most stable metal nanoparticles and easy to synthesize in various sizes; there is a protocol to modify these nanoparticles with additional functionality, and they possess unique properties such as strong adsorption ability, large specific surface area, good biocompatibility, and conductivity [ 25 , 26 , 27 , 28 ]. Various techniques are available for synthesizing AuNPs, including chemical, thermal, electrochemical, and sonochemical methods [ 29 ].…”