Label-free electrochemical biosensor with magnetically induced self-assembly for the detection of cancer antigen 125

Yue, Yao; Chen, Xiu; Wang, Jie; Ma, Mingyi; He, Aolin; Liu, Ruijiang

doi:10.1016/j.arabjc.2023.105070

Cited by 6 publications

(1 citation statement)

References 48 publications

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“…Magnetic beads made of iron oxide NP-embedded polymer matrices can self-assemble at specific locations on functionalized surfaces [89]. Yue et al also used a magnetically induced self-assembly technology to establish a label-free electrochemical biosensor on a magnetic nanocomposite to detect biomarker CA125 [90]. Self-assembly has been used to create 2D and 3D bead arrays, enabling high-density immobilization of capture molecules and improved detection performance.…”

Section: Magnetic Beadsmentioning

confidence: 99%

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Cheng,

Yang,

Wang

et al. 2024

Sensors

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Demand is strong for sensitive, reliable, and cost-effective diagnostic tools for cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising diagnostic platforms based on wide-ranging cancer biomarkers owing to the versatility, high sensitivity, and flexibility to perform the multiplexing of beads. This comprehensive review highlights recent trends and innovations in the development of bead-based biosensors for cancer-biomarker detection. We introduce various types of bead-based biosensors such as optical, electrochemical, and magnetic biosensors, along with their respective advantages and limitations. Moreover, the review summarizes the latest advancements, including fabrication techniques, signal-amplification strategies, and integration with microfluidics and nanotechnology. Additionally, the challenges and future perspectives in the field of bead-based biosensors for cancer-biomarker detection are discussed. Understanding these innovations in bead-based biosensors can greatly contribute to improvements in cancer diagnostics, thereby facilitating early detection and personalized treatments.

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Section: Magnetic Beadsmentioning

confidence: 99%