Label-free electrical monitoring of nucleic acid amplification with integrated hydrogel ionic diodes

Xiong, Chenwei; Li, Jie; Li, Luyao; Chen, Long; Zhang, Rong; Mi, Xianqiang; Liu, Yifan

doi:10.1016/j.mtbio.2022.100281

Cited by 5 publications

(6 citation statements)

References 33 publications

(38 reference statements)

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“…The transient current response of the ionic diode at −3.0 to 3.0 V voltage was observed (Figure ). The I – V curves of the ionic diodes had significant asymmetry, whereas the CS and PAAs hydrogels had symmetry, demonstrating that only the CS/PAAs heterojunction has rectification properties. ,− The I – V characteristic curves show that the current density of the ionic diode under reverse bias (−2 V) is 0.0522 mAcm –2 , while the current under forward bias (2 V) is 8.20 times larger than the negative current (0.4276 mAcm –2 ), confirming the rectification behavior of the ionic diode . The homojunction hydrogel composed of a single hydrogel stack was also tested by LSV.…”

Section: Resultsmentioning

confidence: 76%

Porphyrin-Regulated Heterostructured Hydrogel Ionic Diode with a High Rectification Ratio and Output Voltage

Wei,

Zhao,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Nanochannel ionic diodes require extremely complex and expensive fabrication processes. Polyelectrolyte ionic diodes attracted widespread attention among ionic rectification systems due to their simplicity of development and the ability to break the size limits of the nanochannel. However, enhancement of their rectification ratio is still in the exploratory stage. In this study, chitosan (CS) hydrogels and sodium polyacrylate (PAAs) hydrogels were prepared as the substrates for the heterostructured ionic diodes. 5,10,15,20-Tetrakis(4-aminophenyl)-21H,23H-porphyrin (TAPP) was selected to regulate the rectification ratio of ionic diodes. By adding 0.05 wt % TAPP to the CS hydrogel, the rectification ratio of the ionic diode can be increased to 10, which is 4 times larger than that of the undoped ionic diode. In contrast, the rectification ratio of the ionic diodes with TAPP added in the PAAs hydrogel decreases to 2. In addition, the ionic diode composed of the TAPP-doped CS hydrogel and PAAs hydrogel has the characteristics of a high open-circuit voltage. The open-circuit voltage of the 10 mm × 10 mm × 4 mm heterojunction hydrogel reached 370 mV. The ionic diodes can be used as a self-powered power supply device.

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Section: Resultsmentioning

confidence: 76%

Porphyrin-Regulated Heterostructured Hydrogel Ionic Diode with a High Rectification Ratio and Output Voltage

Wei,

Zhao,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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“…Due to these properties, HBIDs are desirable research areas for electrical biosensing. [28] Although diffusion of the small molecules in polyelectrolyte hydrogels has been extensively examined for appliances such as drug delivery, [29] desalination of water, [30] and pressure sensing, [31] the ionic conduction of hydrogels and its role in electronic, there have been relatively few studies on integration in devices. [32,33] The most important problem encountered is the difficulty of producing essential ionic circuit elements such as resistor, transistor, ionic diode, and capacitor with great flexibility and compatibility.…”

Section: Introductionmentioning

confidence: 99%

“…[13,18,[38][39] IDs express artificial or biotic ion channels that exhibit the rectification of ionic current. In the meanwhile, according to the charge densities on the surface, which is modulated and reflects a tuned correction [28] representing the transport behavior, the adsorption of charged molecules can be determined.…”

Section: Introductionmentioning

confidence: 99%

“…As an outcome of the resulting anti-symmetry and a vary in composition to constitute the typical diode response, the ionic diode produces a current-voltage response such that it exhibits an "on state" against the applied positive potential and an "off state" against the negative potential. [42] Since hydrogels are up-and-coming materials for soft electronics, [28] using them to produce flexible and transparent ionic devices and further investigation is necessary. A common denominator for hydrogel synthesis is the utilization of cross-linkers.…”

Section: Introductionmentioning

confidence: 99%

“…Since hydrogels are up‐and‐coming materials for soft electronics, [ 28 ] using them to produce flexible and transparent ionic devices and further investigation is necessary. A common denominator for hydrogel synthesis is the utilization of cross‐linkers.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Guide for Cross‐Linking Modulation: The Record Rectifying Ratio of Hydrogel‐Based Ultra Flexible Ionic Diodes

ÖZBAY KARAKUŞ

2023

Adv Materials Inter

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This study focuses on the effect of cross‐linking mechanisms in the development of hydrogel‐based flexible ionic diodes (HBIDs) with desirable features for ionic devices. The research explores one p‐type hydrogel and a series of n‐type hydrogels with varying cross‐linking ratios, investigating their ion‐conducting properties, morphological and electronic structures, as well as the performance of flexible HBIDs constructed using these hydrogels. The results indicate that the cross‐linking ratio significantly influences ionic conductivity, bulk resistance, and capacitance. Additionally, the HBIDs' ability to maintain their electrical performance under repeated mechanical bending is studied concerning the cross‐linking ratio. Notably, the HBID with the highest cross‐linking ratio (HG/12) exhibits relatively higher current densities (up to 8.9 mA cm−2) and considerably higher rectification ratios (up to 1269). Even after 500 cycles of deformation, the HG/12 diode maintained a rectification ratio of 987, demonstrating its excellent performance and durability.

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Optically Mediated Hydrogel‐Based Ionic Diode

Ren,

Jing,

Ding

et al. 2024

Small

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Ionic diodes with environmentally modulated ion‐rectifying characteristics have attracted much attention and show great promise in the construction of smart devices with environmental adaptability. One immediate challenge is to integrate stimuli responsiveness and ion rectification into one single ionic diode, which requires a close cooperation of chemical principles and device technologies. Herein, an ionic diode based on a photoresponsive hydrogel with optically mediated ion‐rectifying performances is introduced. Relying on the photoresponsive concentration of proton in the hydrogel, the ionic current rectification can be prominently enhanced upon ultraviolet (UV) irradiation. A maximum ionic current rectification ratio of the optically mediated ionic diode about 4 × 105 is achieved. Furthermore, the hydrogel‐based diode can serve as an AND logic gate operated by UV light and voltage bias as two independent inputs. As a proof of concept, to use the optically mediated diode is achieved to modulate the feedback of a robot with logic behaviors. This work provides a novel and valuable strategy for designing functional hydrogel‐based devices with the integration of stimuli‐responsiveness and logic signal processing through chemical approaches.

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Label-free electrical monitoring of nucleic acid amplification with integrated hydrogel ionic diodes

Cited by 5 publications

References 33 publications

Porphyrin-Regulated Heterostructured Hydrogel Ionic Diode with a High Rectification Ratio and Output Voltage

Porphyrin-Regulated Heterostructured Hydrogel Ionic Diode with a High Rectification Ratio and Output Voltage

A Guide for Cross‐Linking Modulation: The Record Rectifying Ratio of Hydrogel‐Based Ultra Flexible Ionic Diodes

Optically Mediated Hydrogel‐Based Ionic Diode

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