Label-free detection of hepatitis B virus using solution immersed silicon sensors

Diware, Mangesh S.; Cho, Hyun Mo; Chegal, Won; Cho, Yong Jai; O, Sang Won; Paek, Se‐Hwan; Kim, Dong Soo; Kim, Kyeong-Suk; Min, Yoon Gi; Jo, Jae Heung; Shin, Chae Ho

doi:10.1116/1.4977075

Cited by 13 publications

(3 citation statements)

References 23 publications

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“…The signal to noise ratio(SNR) has been calculated from the ratio of change in current after antigen capture to the change in baseline current due to intrinsic fluctuations. It is observed that in most of the recent reports, [41][42][43][44][45] the limit of detection is much higher than 1 fM. Though some of the research reports 1 fM detection limit with higher sensitivities than ERGO sensor in buffer and serum 46,47 their SNRs is lower by at least an order of magnitude than that in the present paper.…”

Section: Resultscontrasting

confidence: 55%

Low Noise Field Effect Biosensor with Electrochemically Reduced Graphene Oxide

Basu

Baral

Samanta

et al. 2018

J. Electrochem. Soc.

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Reduced graphene oxide, in various configurations has been extensively researched as field effect transistor (FET) biosensor, but they usually exhibit low signal to noise ratio. In this paper, we report the fabrication of low noise FET biosensors with electrochemically reduced graphene oxide(ERGO) on fluorine doped tin oxide(FTO) glass, directly by electrochemical reduction of GO in solution. It has been observed that the sensor is capable of detecting down to1 fM concentration of Hep-B in serum with a dynamic range from 1 fM to 20 pM, linearity of around 95% and current sensitivity of 1.21 mA. Moreover, the signal to noise ratio is around 80 in serum, which is enhanced by more than one order of magnitude compared to the most sensitive reports. Further, the presence of Hep-B can be confirmed by the Lorentzian nature of noise spectra, which makes the detection more precise. The combined advantages of low cost and clean fabrication coupled with sensitive and reliable performance renders the device suitable for point of care diagnostics.

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Section: Resultscontrasting

confidence: 55%

Low Noise Field Effect Biosensor with Electrochemically Reduced Graphene Oxide

Basu

Baral

Samanta

et al. 2018

J. Electrochem. Soc.

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“…We constructed a LN AFM system (RMS noise ~35 pm) optimized for surface metrology in the semiconductor industry and the uncertainty was estimated by a quantitative method (see Supplementary Table 1 in Supplementary Information) 26–28 . The reliability of surface information is now an essential factor because the results of these measurements can be easily distorted depending on the environment and probe conditions.…”

Section: Introductionmentioning

confidence: 99%

Advanced measurement and diagnosis of the effect on the underlayer roughness for industrial standard metrology

Kim

Moon

Kim

et al. 2019

Sci Rep

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In current nanoscale semiconductor fabrications, high dielectric materials and ultrathin multilayers have been selected to improve the performance of the devices. Thus, interface effects between films and the quantification of surface information are becoming key issues for determining the performance of the semiconductor devices. In this paper, we developed an easy, accurate, and nondestructive diagnosis to investigate the interface effect of hafnium oxide ultrathin films. A roughness scaling method that artificially modified silicon surfaces with a maximum peak-to-valley roughness range of a few nanometers was introduced to examine the effect on the underlayer roughness. The critical overlayer roughness was be defined by the transition of RMS roughness which was 0.18 nm for the 3 nm thick hafnium oxide film. Subsequently, for the inline diagnostic application of semiconductor fabrication, the roughness of a mass produced hafnium film was investigated. Finally, we confirmed that the result was below the threshold set by our critical roughness. The RMS roughness of the mass produced hafnium oxide film was 0.11 nm at a 500 nm field of view. Therefore, we expect that the quantified and standardized critical roughness managements will contribute to improvement of the production yield.

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“…Applications to a fast and sensitive approach in biosensing can be found in [51]. As an example the label-free detection of hepatitis B virus [52] is reported.…”

Section: Ellipsometrymentioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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Direct optical detection has proven to be a highly interesting tool in biomolecular interaction analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis, clinical diagnostics, screening of large data volumes in immunology, cancer therapy, or personalized medicine. In this review, the fundamental optical principles and applications are reviewed. Devices are based on concepts such as refractometry, evanescent field, waveguides modes, reflectometry, resonance and/or interference. They are realized in ring resonators; prism couplers; surface plasmon resonance; resonant mirror; Bragg grating; grating couplers; photonic crystals, Mach-Zehnder, Young, Hartman interferometers; backscattering; ellipsometry; or reflectance interferometry. The physical theories of various optical principles have already been reviewed in detail elsewhere and are therefore only cited. This review provides an overall survey on the application of these methods in direct optical biosensing. The "historical" development of the main principles is given to understand the various, and sometimes only slightly modified variations published as "new" methods or the use of a new acronym and commercialization by different companies. Improvement of optics is only one way to increase the quality of biosensors. Additional essential aspects are the surface modification of transducers, immobilization strategies, selection of recognition elements, the influence of non-specific interaction, selectivity, and sensitivity. Furthermore, papers use for reporting minimal amounts of detectable analyte terms such as value of mass, moles, grams, or mol/L which are difficult to compare. Both these essential aspects (i.e., biochemistry and the presentation of LOD values) can be discussed only in brief (but references are provided) in order to prevent the paper from becoming too long. The review will concentrate on a comparison of the optical methods, their application, and the resulting bioanalytical quality.

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Label-free detection of hepatitis B virus using solution immersed silicon sensors

Cited by 13 publications

References 23 publications

Low Noise Field Effect Biosensor with Electrochemically Reduced Graphene Oxide

Low Noise Field Effect Biosensor with Electrochemically Reduced Graphene Oxide

Advanced measurement and diagnosis of the effect on the underlayer roughness for industrial standard metrology

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

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