Label-free detection of endocrine disrupting chemicals by integrating a competitive binding assay with a piezoelectric ceramic resonator

Hu, Liang; Fong, Chi-Chun; Zou, Li; Wong, Wing Leung; Wu, Rudolf S.S.; Yang, Mengsu

doi:10.1016/j.bios.2013.09.068

Cited by 15 publications

(5 citation statements)

References 61 publications

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“…Biosensors have also been proposed for environmental samples. Recently, Hu et al [119] developed a label-free piezoelectric-based biosensor based on detection of estrogen receptor (ER-α). After incubation with sample containing estrogenic compounds, including E2 and EE2, the depletion of ER-α was assessed.…”

Section: Biological Based Assaysmentioning

confidence: 99%

Analysis of 17-β-estradiol and 17-α-ethinylestradiol in biological and environmental matrices — A review

Barreiros

Queiroz

Magalhães

et al. 2016

Microchemical Journal

122

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The estrogens 17-β-estradiol (E2) and 17-α-ethinylestradiol (EE2) are reported as highly endocrine-disrupting agents, being recently included in an EU watch list regarding emerging aquatic pollutants. Therefore, the monitoring of these chemicals in the different environmental compartments assumes great importance. Moreover, due to the possible adverse effects on living beings, their occurrence on animal tissues and fluids must also be addressed. In recent years, a significant number of studies have described and proposed different analytical methodologies to detect and/or quantify E2 and EE2 mostly in environmental aqueous samples, including sludge and sediments and also in biological matrices such as plasma and tissues. Taking into account the complexity of real matrices and that both estrogens are generally present at trace levels, the development of accurate and reliable techniques for their determination can be quite a challenge. The present review aims at describing the main characteristics of the analytical methods recently used for E2 and EE2 determination in environmental and biological samples. The steps for sample preparation such as analytes extraction, preconcentration and clean-up are discussed and the instrumental based analytical techniques are compared. Furthermore, the application of biological tools to determine the total estrogenicity of environmental samples, as well as their potential combination with instrumental analyses, is highlighted.

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Section: Biological Based Assaysmentioning

confidence: 99%

Analysis of 17-β-estradiol and 17-α-ethinylestradiol in biological and environmental matrices — A review

Barreiros

Queiroz

Magalhães

et al. 2016

Microchemical Journal

122

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“…Various methods have been employed for the determination of BPA, including fluorescence, 19 liquid chromatography coupled with mass spectrometry, 20 high-performance liquid chromatography, 21 gas chromatography coupled with mass spectrometry, 22 enzyme linked immune sorbent assays (ELISA), 23 piezoelectric biosensing, 24 and electrochemical methods. 25−30 Electrochemistry is one of the preferred techniques in environmental and biological analysis because of its portability, simplicity, reliability, short analysis time, low power consumption, inexpensive equipment, and excellent sensitivity.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Various methods have been employed for the determination of BPA, including fluorescence, liquid chromatography coupled with mass spectrometry, high-performance liquid chromatography, gas chromatography coupled with mass spectrometry, enzyme linked immune sorbent assays (ELISA), piezoelectric biosensing, and electrochemical methods. − Electrochemistry is one of the preferred techniques in environmental and biological analysis because of its portability, simplicity, reliability, short analysis time, low power consumption, inexpensive equipment, and excellent sensitivity. Although a variety of electrochemical sensors have been proposed for BPA detection, the detection of BPA at traditional carbon or noble metal electrodes is compromised due to surface fouling and passivation by deposition of radical intermediates and electro-polymerized films of BPA, , leading to attenuated signal as well as reduced sensitivity and reproducibility over time.…”

Section: Introductionmentioning

confidence: 99%

Au Nanoparticles Decorated TiO₂ Nanotube Arrays as a Recyclable Sensor for Photoenhanced Electrochemical Detection of Bisphenol A

Fong

Zhang

et al. 2016

Environ. Sci. Technol.

Self Cite

130

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A photorefreshable and photoenhanced electrochemical sensing platform for bisphenol A (BPA) detection based on Au nanoparticles (NPs) decorated carbon doped TiO2 nanotube arrays (TiO2/Au NTAs) is described. The TiO2/Au NTAs were prepared by quick annealing of anodized nanotubes in argon, followed by controllable electrodeposition of Au NPs. The decoration of Au NPs not only improved photoelectrochemical behavior but also enhanced electrocatalytic activities of the resulted hybrid NTAs. Meanwhile, the high photocatalytic activity of the NTAs allowed the electrode to be readily renewed without damaging the microstructures and surface states after a short UV treatment. The electrochemical detection of BPA on TiO2/Au NTAs electrode was significantly improved under UV irradiation as the electrode could provide fresh reaction surface continuously and the further increased photocurrent resulting from the improved separation efficiency of the photogenerated electron-hole pairs derived from the consumption of holes by BPA. The results showed that the refreshable TiO2/Au NTAs electrode is a promising sensor for long-term BPA monitoring with the detection limit (S/N = 3) of 6.2 nM and the sensitivity of 2.8 μA·μM(-1)·cm(-2).

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“…[2] Owing to the benzene-like chemical structureso fE DCs, they mimic the mechanisms of naturally occurring hormones, such as estrogen and androgens, in vivo and also alter physiological functioning of the endocrine system. [3] Unfortunately,althoughn umerous techniques have been developed to identify EDCs, such as fluorescence, [4] enzyme linked immune sorbent assays (ELISAs), [5] piezoelectric biosensing, [6] chromatographic sensing, [7] and electrochemical sensing, [8] simple and portable methods are required to evaluate endocrine disrupters that are still used in numerous products, including adhesives, inks, paints, flame retardants, and electrical components. Artificial olfactions ystems based on electronics, [9] photonics, [10] and optoelectronics [11] have recently been developed for variousapplications,s uch as food, [12] pharmaceuticals, [13] and explosive monitoring, [14] and these systems have been used in the diagnosis of differentd iseases.…”

Section: Introductionmentioning

confidence: 99%

Identification of Endocrine Disrupting Chemicals using a Virus‐Based Colorimetric Sensor

Moon

Lee

Shin

et al. 2016

Chemistry An Asian Journal

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A simple and portable colorimetric sensor based on M13 bacteriophage (phage) was devised to identify a class of endocrine disrupting chemicals, including benzene, phthalate, and chlorobenzene derivatives. Arrays of structurally and genetically modified M13 bacteriophage were fabricated so as to produce a biomimetic colorimetric sensor, and color changes in the phage arrays in response to several benzene derivatives were characterized. The sensor was also used to classify phthalate and chlorobenzene derivatives as representatives of endocrine disrupting chemicals. The characteristic color patterns obtained on exposure to various benzene derivatives enabled similar chemical structures in the vapor phase to be classified. Our sensing approach based on the use of a genetically surface modified M13 bacteriophage offers a promising platform for portable, simple environmental monitors that could be extended for use in numerous application areas, including food monitoring, security monitoring, explosive risk assessment, and point of care testing.

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Label-free detection of endocrine disrupting chemicals by integrating a competitive binding assay with a piezoelectric ceramic resonator

Cited by 15 publications

References 61 publications

Analysis of 17-β-estradiol and 17-α-ethinylestradiol in biological and environmental matrices — A review

Analysis of 17-β-estradiol and 17-α-ethinylestradiol in biological and environmental matrices — A review

Au Nanoparticles Decorated TiO₂ Nanotube Arrays as a Recyclable Sensor for Photoenhanced Electrochemical Detection of Bisphenol A

Identification of Endocrine Disrupting Chemicals using a Virus‐Based Colorimetric Sensor

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Label-free detection of endocrine disrupting chemicals by integrating a competitive binding assay with a piezoelectric ceramic resonator

Cited by 15 publications

References 61 publications

Analysis of 17-β-estradiol and 17-α-ethinylestradiol in biological and environmental matrices — A review

Analysis of 17-β-estradiol and 17-α-ethinylestradiol in biological and environmental matrices — A review

Au Nanoparticles Decorated TiO2 Nanotube Arrays as a Recyclable Sensor for Photoenhanced Electrochemical Detection of Bisphenol A

Identification of Endocrine Disrupting Chemicals using a Virus‐Based Colorimetric Sensor

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Au Nanoparticles Decorated TiO₂ Nanotube Arrays as a Recyclable Sensor for Photoenhanced Electrochemical Detection of Bisphenol A