Label-free detection of breast cancer cells using a functionalized tilted fiber grating

Xu, Pin; Lin, Wen‐Wei; Jang, Jin; Qu, Haiyan; Hu, Xuehao; Sun, Jinghua; Cui, Yukun

doi:10.1364/boe.454645

Cited by 12 publications

(2 citation statements)

References 36 publications

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“…Some types of OFS also make possible detection of biomarkers at low concentrations and in small volumes [2]. Thus, they become promising in biosensing applications for e.g., breast [3], [4] or lung cancer [5], or venous thromboembolism [6] diagnostics. For some of these applications, especially where capability for in situ monitoring of biological target binding kinetics is expected, the operation principle cannot rely on application of additional labels, such as florescent dyes, indicating presence of the target material on the sensor surface.…”

Section: Introductionmentioning

confidence: 99%

Tailoring Refractive Index and Adlayer Sensitivity of an Optical Fiber Fabry-Perot Interferometer by a Thin Layer Deposition

Burnat¹,

Kwietniewski²,

Bartnik³

et al. 2022

Preprint

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This work discusses the capability of tailoring sensitivity of an optical-fiber-based Fabry–Perot interferometric (FPI) sensor to changes in refractive index (volume) and formation of a layer on the sensor surface (adlayer). A simple single-layer approach shows some disadvantages, especially when refractive index (n) sensing is considered, e.g., there is no shift of the interference pattern in the wavelength domain. The considered FPI sensor is based on two transparent thin films deposited on a single-mode optical fiber’s end face. As the first layer, a high-n titanium oxide (TiO2) was chosen. We show that addition of a second layer of lower n results in the blueshift of spectral pattern with external n (next). Moreover, when an additional layer, e.g., biological one, is formed, a redshift of the pattern appears, what is in contrary to the shift induced by the increase of next. Numerical analysis as well as experiments show that a wide range of materials (with different n and thickness) can be applied as the second layer, influencing both volume and adlayer sensitivities. We have found that when the second layer thickness is tailored to obtain a well spectrally defined pattern, high n contrast between the layers increases the volume sensitivity, while for the moderate n contrast the adlayer sensitivity of the FPI can be enhanced. The proposed approach shows large tuning capability towards desired application, as well as can be easily introduced to large-scale sensor manufacturing.

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Section: Introductionmentioning

confidence: 99%

Tailoring Refractive Index and Adlayer Sensitivity of an Optical Fiber Fabry-Perot Interferometer by a Thin Layer Deposition

Burnat¹,

Kwietniewski²,

Bartnik³

et al. 2022

Preprint

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show abstract

“…Furthermore, an LSPR biosensor is an analytical technique that can detect the interaction of nucleic acid (DNA-RNA), 8) the genetic material of several nm, and ATP or protein of tens to hundreds of nm in size. [9][10][11][12][13][14][15] In particular, LSPR biosensors are expected to be a compact bio-system technology for POCT because electrons distributed in nano metallic particles locally arranged on the surface cause collective vibration by light irradiation. Therefore, LSPR sensors with various nanostructures such as meta-surface, 16,17) nanoparticle, 18,19) and nanohole 20,21) were proposed for sensitive virus detection systems.…”

mentioning

confidence: 99%

Proposal of compact LSPR sensor system by filter-free wavelength sensor

Choi

Sakae

Ide

et al. 2023

Appl. Phys. Express

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A compact localized surface plasmon resonance (LSPR) sensor system integrated with a filter-free wavelength sensor (FFS) for quantitative virus detection methods was demonstrated. The changed transmission spectrum of LSPR sensor by molecule was measured using an FFS as a transducer without a conventional spectrometer. We designed and fabricated gold nanostructures optimized for virus detection. As the concentration of S-protein RBD changed from 0.1 to 10 ng/ml, the change in current ratio from 0.012 to 0.094 was obtained by the FFS. We expect a compact and rapid virus detection system with qualitatively diagnose to be realized using the proposed method.

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A new SOI sensor design for detecting cancer using hybrid waveguide with higher sensitivity than both strip and slot waveguides

Shawky,

El-Malek,

Allam

et al. 2024

Opt Quant Electron

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A new highly accurate optical biomedical sensor is proposed for cancer detection characterized by high sensitivity, small footprint, low cost, and low limit of detection. The sensor is based on double-ring resonators made of silicon on insulator. The type of the waveguide is critical in determining the sensor performance. To compromise the advantages and disadvantages of strip and slot waveguides, a mixed design of both has been introduced in literature at the expense of increased footprint compared to traditional sensors. Indeed, almost 27-fold footprint increase is required to improve the sensitivity by only one third of that of slot waveguide’s sensitivity. In this paper, we introduce a new design that keeps the same footprint of traditional sensors, while achieving high sensitivity. This sensitivity depends on the resonance wavelength shift due to different refractive indices of the biosample. It has the value 109.8 nm/RIU compared to 55.57 nm/RIU and 129.621 nm/RIU for strip and slot waveguides, respectively. The hybrid waveguide quality factor is 537.7 while the quality factors of the strip and the slot waveguides are 627.99 and 380.76, respectively. In addition, the new design achieves the minimum limit of detection (0.0255) when compared to that of traditional designs. Furthermore, a new method of detection is proposed with the same design, providing a higher sensitivity over both traditional waveguide types with a value of 15.3, compared to 13.2 and 11.5 for strip and slot waveguides, respectively. In this method, the sensitivity relies on various values of output transmitted light at the same wavelength due to altering the biocell refractive index. The biosensor output equation is developed. In addition, the relationship between the supermodes and the sensitivity is determined at variance conditions. It is found that there is an inverse relation between them.

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Label-free detection of breast cancer cells using a functionalized tilted fiber grating

Cited by 12 publications

References 36 publications

Tailoring Refractive Index and Adlayer Sensitivity of an Optical Fiber Fabry-Perot Interferometer by a Thin Layer Deposition

Tailoring Refractive Index and Adlayer Sensitivity of an Optical Fiber Fabry-Perot Interferometer by a Thin Layer Deposition

Proposal of compact LSPR sensor system by filter-free wavelength sensor

A new SOI sensor design for detecting cancer using hybrid waveguide with higher sensitivity than both strip and slot waveguides

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