Label-free colorectal cancer cell line bio-sensing using RF resonator

Zhang, Ling Yan; Landoulsi, Alaeddine; Puch, Christophe Bounaix Morand Du; Lacroix, Aurélie; Dalmay, Claire; Bessaudou, Annie; Lautrette, Christophe; Battu, Serge; Lalloué, Fabrice; Jauberteau, Marie‐Odile; Blondy, Pierre; Pothier, A.

doi:10.1109/transducers.2013.6626987

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…To contribute to the advancement of this relevant and timely field of research, the present article is devoted to the extraction of an equivalent-circuit model and to the resonance-based investigation of the permittivity sensitivity, considering as case study a one-port coplanar interdigital capacitor (IDC) aimed at microfluidic broadband bioelectronics applications. Over the past few decades, interest in capacitors based on interdigital electrodes (IDE) has expanded from the traditional applications in communication systems [42] to the more recent ones in the biosensing field [12,30,37,[43][44][45][46]. Although a few studies have been reported on exploiting this resonance of the IDC structure for biosensing purpose [45], the biomaterial characterization is advantageous at relatively low frequencies to avoid the onset of IDC self-resonance effects [37].…”

Section: Introductionmentioning

confidence: 99%

“…Over the past few decades, interest in capacitors based on interdigital electrodes (IDE) has expanded from the traditional applications in communication systems [42] to the more recent ones in the biosensing field [12,30,37,[43][44][45][46]. Although a few studies have been reported on exploiting this resonance of the IDC structure for biosensing purpose [45], the biomaterial characterization is advantageous at relatively low frequencies to avoid the onset of IDC self-resonance effects [37]. Nevertheless, different biological materials can show different dispersion properties at different frequency ranges, so it is necessary to analyze the spectroscopy of biological materials in a broad band.…”

Section: Introductionmentioning

confidence: 99%

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Biosensor Using a One-Port Interdigital Capacitor: A Resonance-Based Investigation of the Permittivity Sensitivity for Microfluidic Broadband Bioelectronics Applications

et al. 2020

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Electronics is a field of study ubiquitous in our daily lives, since this discipline is undoubtedly the driving force behind developments in many other disciplines, such as telecommunications, automation, and computer science. Nowadays, electronics is becoming more and more widely applied in life science, thus leading to an increasing interest in bioelectronics that is a major segment of bioengineering. A bioelectronics application that has gained much attention in recent years is the use of sensors for biological samples, with emphasis given to biosensors performing broadband sensing of small-volume liquid samples. Within this context, this work aims at investigating a microfluidic sensor based on a broadband one-port coplanar interdigital capacitor (IDC). The microwave performance of the sensor loaded with lossless materials under test (MUTs) is achieved by using finite-element method (FEM) simulations carried out with Ansoft's high frequency structure simulator (HFSS). The microfluidic channel for the MUT has a volume capacity of 0.054 µL. The FEM simulations show a resonance in the admittance that is reproduced with a five-lumped-element equivalent-circuit model. By changing the real part of the relative permittivity of the MUT up to 70, the corresponding variations in both the resonant frequency of the FEM simulations and the capacitance of the equivalent-circuit model are analyzed, thereby enabling assessment of the permittivity sensitivity of the studied IDC. Furthermore, it is shown that, although the proposed local equivalent-circuit model is able to mimic faithfully the FEM simulations locally around the resonance in the admittance, a higher number of circuit elements can achieve a better agreement between FEM and equivalent-circuit simulation over the entire broad frequency going range from 0.3 MHz to 35 GHz.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biosensor Using a One-Port Interdigital Capacitor: A Resonance-Based Investigation of the Permittivity Sensitivity for Microfluidic Broadband Bioelectronics Applications

et al. 2020

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“…Over a few decades, biomolecule sensing technique using a microwave has been proposed for its highly sensitive, rapid and reliable measurement [8]- [12]. This is mainly due to the γ dispersion which a microwave causes shows a significant variation in the dielectric constant.…”

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confidence: 99%

“…This paper proposes a fully-integrated circuit based on CMOS composed with a biosensor referred to the previous study [12] and an on-chip VNA for CTC analysis. The proposal is expected to achieve more accurate and sensitive analysis of CTC owing to the elimination of the undesired parasitic effects from substrate and cables in comparison with other papers [8]- [12].…”

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confidence: 99%

A 65-nm CMOS Fully Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome

Niitsu

Nakanishi

Murakami

et al. 2019

IEEE Trans. Biomed. Circuits Syst.

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A fully integrated CMOS circuit based on a vector network analyzer and a transmission-line-based detection window for circulating tumor cell (CTC) and exosome analysis is presented for the first time. We have introduced a fully integrated architecture, which eliminates the undesired parasitic components and enables high-sensitivity, to analyze extremely low-concentration CTC in blood. The detection window was designed on the high-sensitive coplanar waveguide line. To validate the operation of the proposed system, a test chip was fabricated using 65-nm CMOS technology. Measurements were performed after adding a tiny lump of silicone or a droplet of water on its detection window. The measured results show |S_21| degradation of −1.96 dB and −6.04 dB for the silicone and the droplet, respectively, at 1.4 GHz. In addition, in another measurement using magnetic beads, it is confirmed that the proposed circuit can analyze even low concentrations of 20 beads/µL.

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A fully-integrated circulating tumor cell analyzer using an on-chip vector network analyzer and a transmission-line-based detection window in 65-nm CMOS

Nakanishi

Matsunaga

Kobayashi

et al. 2017

2017 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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Label-free colorectal cancer cell line bio-sensing using RF resonator

Cited by 7 publications

References 6 publications

Biosensor Using a One-Port Interdigital Capacitor: A Resonance-Based Investigation of the Permittivity Sensitivity for Microfluidic Broadband Bioelectronics Applications

Biosensor Using a One-Port Interdigital Capacitor: A Resonance-Based Investigation of the Permittivity Sensitivity for Microfluidic Broadband Bioelectronics Applications

A 65-nm CMOS Fully Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome

A fully-integrated circulating tumor cell analyzer using an on-chip vector network analyzer and a transmission-line-based detection window in 65-nm CMOS

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