Label-free and non-destructive histology of unprocessed biological tissues with ultraviolet single-plane illumination microscopy
Yan Zhang,
Bingxin Huang,
Weixing Dai
et al.
Abstract:Histopathology has remained the gold standard for surgical margin assessment for decades. However, routine pathological examination based on formalin-fixed and paraffin-embedded (FFPE) tissues is laborious and time-consuming, failing to guide surgeons intraoperatively. Here, we propose a rapid, label-free, and non-destructive histological imaging method, termed microscopy with ultraviolet single-plane illumination (MUSI). With intrinsic fluorescence from deep ultraviolet excitation, MUSI enables both ex vivo a… Show more
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