Abstract:Glioblastoma development should be subdivided in three phases, one prehypoxic and two post-hypoxic phases. The pre-hypoxic phase, ranging from 10% to 5% oxygen (normal brain oxygen levels), should be characterized only by CD133-cells, and these cells are inevitably also those that first conquer and microinfiltrate the brain parenchyma. In some areas of the bulk, the oxygen concentration falls to about 5% or less, and hypoxia develops. The second phase ranges from about 5% to about 1% oxygen concentration. This… Show more
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