Lab on Paper: Iodometric Titration on a Printed Card

Myers, Nicholas M.; Kernisan, Emalee N.; Lieberman, Marya

doi:10.1021/ac504269q

Cited by 49 publications

(44 citation statements)

References 20 publications

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“…It should be also noted that the flexibility in designing microfluidic patterns allowed for multiplex assays to be conducted on a single device. [5][6][7][8][9][10] For the fabrication of μPADs, the primary challenge is to modify the wettability of paper substrates (i.e., from hydrophilic to hydrophobic). In the past decade , several methods have been developed to fabricate hydrophobic paper substrates, which were based on either physical deposition 5,[19][20][21] or chemical modification approaches.…”

Section: Introductionmentioning

confidence: 99%

Superhydrophobic Substrates from Off-the-Shelf Laboratory Filter Paper: Simplified Preparation, Patterning, and Assay Application

Zhang

Kwok

et al. 2017

ACS Appl. Mater. Interfaces

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Off-the-shelf laboratory filter paper of different pore sizes and thicknesses can be modified with fluorine-free organosilanes to be superhydrophobic, patternable, and ready for quantitative assay applications. In particular, we have demonstrated that the cellulose filter paper treated with a binary hexane solution of short (methyltrichlorosilane) and long (octadecyltrichlorosilane) organosilanes exhibits remarkably high water contact angles (>150°) and low wetting hysteresis (∼10°). Beyond the optimized ratio between the two organosilanes, we have discovered that the thickness rather than the pore size dictates the resulting superhydrophobicity. Scanning electron microscopy images showed that silanization does not damage the cellulose microfibers; instead, they are coated with uniform, particulate nanostructures, which should contribute to the observed surface properties. The modified filter paper is chemically stable and mechanically durable; it can be readily patterned with UV/ozone treatment to create hydrophilic regions to prepare chemical assays for colorimetric pH and nitrite detections.

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Section: Introductionmentioning

confidence: 99%

Superhydrophobic Substrates from Off-the-Shelf Laboratory Filter Paper: Simplified Preparation, Patterning, and Assay Application

Zhang

Kwok

et al. 2017

ACS Appl. Mater. Interfaces

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“…Finally, we demonstrated the valve in an iodate assay reported by Lieberman and co‐workers . Briefly, this assay is composed of the analyte (KIO 3 − ), three reagents (p‐toluenosulfonic acid, KI, Na 2 S 2 O 3 ), and a starch indicator that produces the colorimetric output signal.…”

Section: Properties Of the Three Woven Materials For Electrowettingmentioning

confidence: 99%

Electrical Textile Valves for Paper Microfluidics

et al. 2017

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This paper describes electrically activated fluidic valves that operate based on electrowetting through textiles. The valves are fabricated from electrically conductive, insulated, hydrophobic textiles, but the concept could be extended to other porous materials. When the valve is closed, the liquid cannot pass through the hydrophobic textile. Upon application of a potential (in the range of 100 -1000 Volts) between the textile and the liquid, the valve opens and the liquid penetrates the valve. These valves actuate in less than 1 second, require low energy (~27 µJ per actuation), and work with a variety of aqueous solutions, including low surface tension aqueous liquids, and bioanalytes. They are bistable in function, and are in a sense, the electrofluidic analog of thyristors. They can be integrated into paper microfluidic devices to make circuits that are capable of liquid control, including autonomous fluidic timers, and fluidic logic. 2Paper microfluidics is a technology particularly well-suited for uses in public health, point of care diagnostics for resource-limited settings, veterinary medicine, food and water quality testing, and environmental monitoring. [1], [2], [3], [4], [5], [6], [7], [8] Many common assays require the addition of multiple reagents and multiple washing steps, where the timing of each step influences the outcome of the assay. For example, paper-based devices for ELISA [9,10], [11], [12] , electrochemiluminescence (ECL) [13] , or DNA detection [14], [15] , require multiple individually timed steps of binding, washing and amplification. Performing these steps manually is labor intensive (a single assay may take from several minutes to hours) and prone to human errors. Fully automated paper-based assays have the potential to be faster and more accurate than those requiring human operations.The most important component required for autonomous assays is a fluidic valve that gates the flow of liquids with timed actuation. Different methods of valving have been explored for paper devices [16], [17], [18], [19], [20], [21], [22], [23] , which operate either by changing the wicking properties of the paper or by mechanically altering connectivity between the channels.Wicking speed in the paper is determined by three parameters: The hydrophilicity of its surface, the size of the pores, and the viscosity of the liquid. These parameters can be altered to actuate flow of liquids. For example, hydrophobic surfaces can be rendered hydrophilic by an electrical plasma [16] or by electrochemical [17,24] or ultraviolet modification. [25] Surfactants can also be used to assist liquids in crossing the hydrophobic barriers [23,26,27] ; dissolved polymers [28] or sugars [29] can increase the viscosity of the liquids and limit the flow.Mechanical motion of paper has also been used for actuating the flow of liquids in paper. Electromagnetic [18] , hygroexpanding [19], [30] manually operated push-buttons [20] , flaps [21] , pop-up [31] , folding [10], [32] and sliding strip [14] concepts for valving h...

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“…It is important to note here that the applications of such paper-based devices are not only limited in the field of diagnostics, but have also been extended to address diverse applications like titration (Myers et al 2015;Karita and Kaneta 2014), power generation (Arun et al 2014;Veerubhotla et al 2015) (fuel-cells), and the development of flexible electronics etc.…”

Section: Paper-based Devicesmentioning

confidence: 99%

Microfluidics-based Low-Cost Medical Diagnostic Devices: Some Recent Developments

2016

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Here we present a short review of recently developed low-cost microfluidic devices aimed towards medical diagnostic applications. This review specifically focuses on three inexpensive devices, namely lab-on-acompact-disc, paper-based, and thread-based devices. Here, we present a concise summary of all the recently developed protocols for simple bioassays to complex diagnostics. We also provide a new outlook on how the present practice of pathological diagnostics can be improved with the usage of such recent developments.

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Lab on Paper: Iodometric Titration on a Printed Card

Cited by 49 publications

References 20 publications

Superhydrophobic Substrates from Off-the-Shelf Laboratory Filter Paper: Simplified Preparation, Patterning, and Assay Application

Superhydrophobic Substrates from Off-the-Shelf Laboratory Filter Paper: Simplified Preparation, Patterning, and Assay Application

Electrical Textile Valves for Paper Microfluidics

Microfluidics-based Low-Cost Medical Diagnostic Devices: Some Recent Developments

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