Lab-on-a-Chip Technologies for the Single Cell Level: Separation, Analysis, and Diagnostics

Hochstetter, Axel

doi:10.3390/mi11050468

Cited by 28 publications

(19 citation statements)

References 220 publications

(338 reference statements)

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“…In recent years, monodisperse droplet generation technology has been widely used in the fields of additive manufacturing [ 1 , 2 ], inkjet printing [ 3 , 4 ], electronic packaging [ 5 , 6 ], bioengineering [ 7 , 8 , 9 ], instrument calibration [ 10 , 11 ], etc. It has prompted many researchers to become engaged in developing droplet generation techniques to meet new requirements such as droplets that are highly uniform and monodisperse in terms of their size, shape, density, and surface characteristics, with a variety of solutes and solvents.…”

Section: Introductionmentioning

confidence: 99%

Formation and Elimination of Satellite Droplets during Monodisperse Droplet Generation by Using Piezoelectric Method

Yang

et al. 2021

Micromachines

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One of the key questions in the generation of monodisperse droplets is how to eliminate satellite droplets. This paper investigates the formation and elimination of satellite droplets during the generation of monodisperse deionized water droplets based on a piezoelectric method. We estimated the effects of two crucial parameters—the pulse frequency for driving the piezoelectric transducer (PZT) tube and the volume flow rate of the pumping liquid—on the generation of monodisperse droplets of the expected size. It was found that by adjusting the pulse frequency to harmonize with the volume flow rate, the satellite droplets can be eliminated through their coalescence with the subsequent mother droplets. An increase in the tuning pulse frequency led to a decrease in the size of the monodisperse droplets generated. Among three optimum conditions (OCs) (OC1: 20 mL/h, 20 kHz; OC2: 30 mL/h, 30 kHz; and OC3: 40 mL/h, 40 kHz), the sizes of the generated monodisperse deionized water droplets followed a bimodal distribution in OC1 and OC2, whereas they followed a Gaussian distribution in OC3. The average diameters were 87.8 μm (OC1), 85.9 μm (OC2), and 84.8 μm (OC3), which were 8.46%, 6.14%, and 4.69% greater than the theoretical one (81.0 μm), respectively. This monodisperse droplet generation technology is a promising step in the production of monodisperse aerosols for engineering applications.

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Section: Introductionmentioning

confidence: 99%

Formation and Elimination of Satellite Droplets during Monodisperse Droplet Generation by Using Piezoelectric Method

Yang

et al. 2021

Micromachines

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“…Thus, the advantages of BoC systems has led to substantial advancements in point-of-care (PoC) diagnostic applications [ 29 ], including cancer, a neurodegenerative disorder, and infectious disease diagnosis [ 34 ]. Such devices could bring significant improvements, especially in the resource-limited environment of the developing countries, as it has brought diagnostics out of central laboratories to the patient bedside [ 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Biosensors-on-Chip: An Up-to-Date Review

et al. 2020

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Generally, biosensors are designed to translate physical, chemical, or biological events into measurable signals, thus offering qualitative and/or quantitative information regarding the target analytes. While the biosensor field has received considerable scientific interest, integrating this technology with microfluidics could further bring significant improvements in terms of sensitivity and specificity, resolution, automation, throughput, reproducibility, reliability, and accuracy. In this manner, biosensors-on-chip (BoC) could represent the bridging gap between diagnostics in central laboratories and diagnostics at the patient bedside, bringing substantial advancements in point-of-care (PoC) diagnostic applications. In this context, the aim of this manuscript is to provide an up-to-date overview of BoC system development and their most recent application towards the diagnosis of cancer, infectious diseases, and neurodegenerative disorders.

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“…[ 1,2 ] Arrays of magnetic micro‐objects are being used in microfluidics, for droplet manipulation and particle trapping purposes. [ 3–5 ] Lab‐on‐a‐chip platforms containing lithographed magnetic materials are utilized for single‐cell positioning and confinement, as well as to guide cell growth and cell migration (i.e., micro‐tissue engineering). [ 3,6–8 ] At the sub‐micron length scale, periodic arrays of hard magnetic patterned dots have allowed a drastic increase of the areal density of information in hard disk drives.…”

Section: Introductionmentioning

confidence: 99%

Voltage‐Induced ON Switching of Magnetism in Ordered Arrays of Non‐Ferrimagnetic Nanoporous Iron Oxide Microdisks

Cialone

Nicolenco

Robbennolt

et al. 2020

Adv Materials Inter

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Tailoring the magnetic properties of ordered arrays of patterned structures usually requires stringent control of their size, pitch, microstructure, and composition. Here, a fundamentally different approach to manipulate the magnetic behavior of lithographed microdisks, based on the application of electrical voltage, is demonstrated. First, highly porous iron oxide films with virtually no magnetic response (OFF state) are grown by sol–gel chemistry. Subsequently, arrays of microdisks (8 µm in diameter) are obtained combining lithography with wet chemical etching processes. Electrolyte‐gating (with an anhydrous electrolyte) is then employed to induce a tunable (i.e., “on‐demand”) ferromagnetic response in these disks (OFF–ON switching of magnetism) at room temperature. The changes in magnetic properties are attributed to magnetoelectrically‐driven oxygen ion migration, which is enhanced due to nanoporosity. This causes partial reduction of the oxide phases to metallic Fe. The effect can be considerably reversed by applying voltage of opposite polarity. These results are appealing for diverse technological applications that require the use of patterned structures with easily tunable magnetic properties, such as magnetic micro‐electro‐mechanical systems, microfluidic, and lab‐on‐a‐chip platforms for biomedical therapies and, ultimately, energy‐efficient magnetic memories or neuromorphic computing.

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Lab-on-a-Chip Technologies for the Single Cell Level: Separation, Analysis, and Diagnostics

Cited by 28 publications

References 220 publications

Formation and Elimination of Satellite Droplets during Monodisperse Droplet Generation by Using Piezoelectric Method

Formation and Elimination of Satellite Droplets during Monodisperse Droplet Generation by Using Piezoelectric Method

Biosensors-on-Chip: An Up-to-Date Review

Voltage‐Induced ON Switching of Magnetism in Ordered Arrays of Non‐Ferrimagnetic Nanoporous Iron Oxide Microdisks

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