Lab-on-a-Chip Platforms for Detection of Cardiovascular Disease and Cancer Biomarkers

Wu, Jiandong; Dong, Meili; Santos, Susy; Rigatto, Claudio; Liu, Yong; Lin, Francis

doi:10.3390/s17122934

Cited by 65 publications

(48 citation statements)

References 82 publications

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“…The heart is a vital organ that pumps blood through blood vessels to provide oxygen (O 2 ) and nutrients throughout the entire body and to remove carbon dioxide (CO 2 ) and metabolic waste from the body. The World Health Organization estimated that cardiovascular diseases (CVDs), i.e., heart and blood vessel diseases, are responsible for up to ≈30% of the total number of deaths worldwide . Since CVDs become much easier to manage when detected early, there is an increasing need for continuous cardiovascular monitoring .…”

Section: Introductionmentioning

confidence: 99%

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Hong

Jeong

Cho

et al. 2019

Adv Funct Materials

394

271

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Cardiovascular disease is the leading cause of death and has dramatically increased in recent years. Continuous cardiac monitoring is particularly important for early diagnosis and prevention, and flexible and stretchable electronic devices have emerged as effective tools for this purpose. Their thin, soft, and deformable features allow intimate and long-term integration with biotissues, which enables continuous, high-fidelity, and sometimes large-area cardiac monitoring on the skin and/or heart surface. In addition to monitoring, intimate contact is also crucial for high-precision therapies. Combined with tissue engineering, soft bioelectronics have also demonstrated the capability to repair damaged cardiac tissues. This review highlights the recent advances in wearable and implantable devices based on flexible and stretchable electronics for cardiovascular monitoring and therapy. First, wearable/implantable soft bioelectronics for cardiovascular monitoring (e.g., the electrocardiogram, blood pressure, and oxygen saturation level) are reviewed. Then, advances in cardiovascular therapy based on soft bioelectronics (e.g., mesh pacing, ablation, robotic sleeves, and electronic stents) are discussed. Finally, device-assisted tissue engineering therapy (e.g., functional electronic scaffolds and in vitro cardiac platforms) is discussed.

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Section: Introductionmentioning

confidence: 99%

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Hong

Jeong

Cho

et al. 2019

Adv Funct Materials

394

271

View full text Add to dashboard Cite

show abstract

“…Microfluidic lab‐on‐a‐chip devices have drawn significant attention in recent years because of their unique characteristics including short time assay , requiring low reagent volume , having the ability to integrate multiple processes into one platform , low‐cost production , and simple process control .…”

Section: Introductionmentioning

confidence: 99%

Novel microfluidic graphene oxide–protein amperometric biosensor for detecting sulfur compounds

Ghaemi

Abdi

Javadi

et al. 2019

Biotech and App Biochem

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Sulfur compounds are essential for many industries and organisms; however, they cause serious respiratory problems in human beings. Therefore, determination of sulfur concentration is of paramount importance. The research approach in the field of detecting contaminants has led to smaller systems that provide faster and more effective ways for diagnosis purposes. In this study, a novel portable amperometric graphene oxide-protein biosensor platform is investigated. The main characteristic of this structure is the implementation of a microfluidic configuration. With albumin metalloprotein as the biorecognition element, graphene oxide was synthesized and characterized by transmission electron microscopy and Fourier-transform infrared spectroscopy (FTIR). Albumin protein was stabilized on the surface of graphene oxide by the application of the N-(3-dimethylamionpropyl)-N-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide method. The stabilization was confirmed by FTIR and electrochemistry analyses. The calibration curve of sulfur concentration was determined. When the graphene oxide-protein complex was stabilized by nephion on the surface of the microfluidic system, the response time reduced to 50 Sec, which is a relatively faster response among the similar studies and validated the significant effect of the microfluidic system. The nanosystem had an optimized pH of 7.4 and exhibited high sensitivity in determining sulfide. The results confirm that the portable graphene oxide-protein nanosystem has a fast and accurate response in detecting sulfide.

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“…Microfluidic technology was employed in microanalytical methods to achieve measurements or results of high sensitivity and high resolution. Its ability to be integrated with various novel detection techniques has made it versatile [21]. The most common detection methods used in conjunction with microfluidics are electrochemical such as amperometry [22][23][24] and optical such as absorbance [25] or chemiluminescence [26].…”

Section: Introductionmentioning

confidence: 99%

Performance Evaluation of Free-Space Fibre Optic Detection in a Lab-on-Chip for Microorganism

et al. 2019

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This paper describes the development of a lab-on-chip (LOC) device that can perform reliable online detection in continuous-flow systems for microorganisms. The objective of this work was to examine the performance of a fibre optic detection system integrated into a LOC device. The microfluidic system was fabricated using dry film resist (DFR), integrated with multimode fibre pigtails in the LOC. Subsequently, the performance of the fibre optic detection was evaluated by its absorbance spectra, detection limit, repeatability and reproducibility, and response time. The analysis was carried out using a constant flow rate for three different types of microorganisms which are Escherichia coli, Saccharomyces cerevisiae, and Aeromonas hydrophila. Under the experimental conditions used in this study, the detection limit of 1.0×105 cells/mL for both A. hydrophila and E. coli, while a detection limit of 1.0×106 cells/mL for S. cerevisiae cells were measured. The results also revealed that the device showed good repeatability with standard deviations less than 0.2 for A. hydrophila and E. coli, while standard deviations for S. cerevisiae were larger than 1.0. The response times for A. hydrophila, E. coli, and S. cerevisiae were 104 s, 122 s, and 78 s, respectively, although significant errors were recorded for all three species for reproducibility experiment. It was found that the device showed generally good sensitivity, with the highest sensitivity towards S. cerevisiae. These findings suggest that an integrated LOC device, with embedded multimode fibre pigtails, can be a reliable instrument for microorganism detection.

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Lab-on-a-Chip Platforms for Detection of Cardiovascular Disease and Cancer Biomarkers

Cited by 65 publications

References 82 publications

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics

Novel microfluidic graphene oxide–protein amperometric biosensor for detecting sulfur compounds

Performance Evaluation of Free-Space Fibre Optic Detection in a Lab-on-Chip for Microorganism

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