Lab-grown embryos; 3D genome architecture; preterm outcomes

Abstract

WEEK OF SEPTEMBER 11 THhuman stem cells can grow into a laboratory embryo that meets key developmental milestones. Spectrum has previously reported on lab-grown mouse embryos created by the same research group. Nature children and adolescents engage in camouflaging behaviors to fit into non-autistic settings, which can be stressful even as it becomes habitual. Research in Autism Spectrum Disorders Genetic engineering of human stem cells to create commonly observed deletions on chromosome 15 may provide more consistent cell models of Angelman and Prader-Willi syndromes, according to a preprint. bioRxiv The 3D genome architecture of cerebellar cells is remodeled across the lifespan -in both mice and people. Spectrum covered this research last year, before its publication. Science Mice carrying variants of the autism-linked SHANK3 gene show behavioral changes that are mitigated by oral acetate treatment. Brain, Behavior, and Immunity Ubadah Sabbagh, a Massachusetts Institute of Technology researcher born in Syria, has won the 2023 Young Arab Pioneers Award and other accolades for his research on brain circuits involved in neurodevelopmental conditions. The McGovern Institute People with variants of the gene TBL1XR1 show a wide range of phenotypes, including autism, global developmental delay, hypotonia and epilepsy. Gene Mice missing the autism-linked gene FOXP1 in the cortex show changes in cortical neuron structure, altered responses to tactile stimuli and heightened fear responses. Molecular Autism Barrel roles: Cortical serotonin staining shows structural form development in wildtype mice (left) and those missing FOXP1 (right).