La voie Nrf2 en pathologie respiratoire

Boutten, Anne; Goven, Delphine; Artaud-Macari, Élise; Bonay, Marcel

doi:10.1051/medsci/20112711012

Cited by 5 publications

(4 citation statements)

References 45 publications

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“…It is now well known that Nrf2 plays an essential role in maintaining redox homeostasis and protecting against oxidative insults (see other reviews in this issue), and that Nrf2 dysregulation is implicated in various oxidative stress-related diseases including cardiovascular diseases [208], neurodegenerative diseases [209], pulmonary diseases [210], cancers [211], and other pathologies [212]. …”

Section: Introductionmentioning

confidence: 99%

Oxidative stress response and Nrf2 signaling in aging

Zhang¹,

Davies

Forman

2015

Free Radical Biology and Medicine

652

504

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Increasing oxidative stress, a major characteristic of aging, has been implicated in variety of age-related pathologies. In aging, oxidant production from several sources is increased while antioxidant enzymes, the primary lines of defense, are decreased. Repair systems, including the proteasomal degradation of damaged proteins also declines. Importantly, the adaptive response to oxidative stress declines with aging. Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant enzymes and the proteasome. Nrf2/EpRE activity is regulated at several levels including transcription, post-translation, and interaction with other proteins. This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the change of Nrf2 regulatory mechanisms with aging.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress response and Nrf2 signaling in aging

Zhang¹,

Davies

Forman

2015

Free Radical Biology and Medicine

652

504

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“…I-FABP is located mainly in the enterocytes of the small intestine, and is released into the blood stream after intestinal ischemia and cell disruption [ 4 ]. MMP3 as well as their inhibitors (TIMPs) play a crucial role in the repairation of extracorpuscular matrix homeostasis, which is expressed at high levels in the intestine of clinical IBD and celiac diseases [ 5 ]. In this research, mRNA levels of these three genes in STa group were simultaneously less than that in control group, these data showed that LMG194-STa could obviously caused the damage of the colon.…”

Section: Discussionmentioning

confidence: 99%

Injury and mechanism of recombinant <i>E. coli</i> expressing STa on piglets colon

Zhang

et al. 2018

The Journal of Veterinary Medical Science

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Enterotoxigenic Escherichia coli (ETEC) is primary pathogenic bacteria of piglet diarrhea, over two thirds of piglets diarrhea caused by ETEC are resulted from STa-producing ETEC strains. This experiment was conducted to construct the recombinant E. coli expressing STa and study the injury and mechanism of recombinant E. coli expressing STa on 7 days old piglets colon. Twenty-four 7 days old piglets were allotted to four treatments: control group, STa group (2 × 109 CFU E. coli LMG194-STa), LMG194 group (2 × 109 CFU E. coli LMG194) and K88 group (2 × 109 CFU E. coli K88). The result showed that E. coli infection significantly increased diarrhea rates; changed DAO activity in plasma and colon; damaged colonic mucosal morphology including crypt depth, number of globet cells, density of lymphocytes and lamina propria cell density; substantially reduced antioxidant capacity by altering activities of GSH-Px, SOD, and TNOS and productions of MDA and H2O2; obviously decreased AQP3, AQP4 and KCNJ13 protein expression levels; substantially altered the gene expression levels of inflammatory cytokines. Conclusively, STa group had the biggest effect on these indices in four treatment groups. These results suggested that the recombinant strain expressed STa can induce piglets diarrhea and colonic morphological and funtional damage by altering expression of proteins connect to transportation function and genes associated with intestinal injury and inflammatory cytokines.

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“…T A B L E 1 Phenothiazine as a free radical scavenger. The impairment of Nrf2 signaling can compromise the cellular responses to oxidative stress, contributing to the pathogenesis of several diseases, such as respiratory, [44,45] neurodegenerative, [46][47][48] and cardiovascular diseases. [49] Within cells, Nrf2 synthesis and transport inside the nucleus, are low under basal conditions due to its association with Kelch-like ECH-associated protein 1 (Keap1), [50] the latter a substrate adaptor protein for the Cullin3-containing E3-ligase complex, targets Nrf2 for ubiquitination and degradation through the ubiquitin proteasome system.…”

Section: Ptz As Nrf2/are Pathway Modulatorsmentioning

confidence: 99%

Phenothiazines: Nrf2 activation and antioxidant effects

Egbujor,

Tucci,

Buttari

et al. 2024

J Biochem & Molecular Tox

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Phenothiazines (PTZs) are an emerging group of molecules showing effectiveness toward redox signaling and reduction of oxidative injury to cells, via the activation on Kelch‐like ECH‐associated protein 1/nuclear factor erythroid 2‐related factor 2 (Nrf2). Although several electrophilic and indirect Nrf2 activators have been reported, the risk of “off‐target” effect due to the complexity of their molecular mechanisms of action, has aroused research interest toward non‐electrophilic and direct modulators of Nrf2 pathway, such as PTZs. This review represents the first overview on the roles of PTZs as non‐electrophilic Nrf2 activator and free radical scavengers, as well as on their potential therapeutic effects in oxidative stress‐mediated diseases. Here, we provide a collective and comprehensive information on the PTZs ability to scavenge free radicals and activate the Nrf2 signaling pathway, with the aim to broaden the knowledge of their therapeutic potentials and to stimulate innovative research ideas.

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La voie Nrf2 en pathologie respiratoire

Cited by 5 publications

References 45 publications

Oxidative stress response and Nrf2 signaling in aging

Oxidative stress response and Nrf2 signaling in aging

Injury and mechanism of recombinant <i>E. coli</i> expressing STa on piglets colon

Phenothiazines: Nrf2 activation and antioxidant effects

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