La vacunación en medicina de la conservación

Plumb, Glenn E.; Babiuk, Lorne A.; Mazet, Jonna A. K.; Olsen, Steven C.; Rupprecht, Charles E.; Pastoret, Paul-Pierre; Slate, Dennis

doi:10.20506/rst.26.1.1740

Cited by 21 publications

(1 citation statement)

References 55 publications

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“…Vaccine production remains a long-term solution for DFTD control. Vaccination is a cornerstone of disease prevention in veterinary and human medicine, and is playing an increasingly important role in wildlife disease control (Plumb et al, 2007). The age of targeted cancer therapy was heralded by the development of imatinib, a tyrosine kinase inhibitor that acts directly on the fusion gene product created by the Ph chromosome rearrangement in CML patients (Deininger and Druker, 2003).…”

Section: Disease Managementmentioning

confidence: 99%

Devil Facial Tumour Disease (DFTD): Using Genetics and Genomics to Investigate Infectious Disease in an Endangered Marsupial

Bender

2010

Marsupial Genetics and Genomics

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The Tasmanian devil (Sarcophilus harrisii), so named for its blood-curdling, nocturnal shrieks and snarls, is the largest of the carnivorous marsupials. Although once widely persecuted, concerted efforts are now being made to save the devil from extinction following the emergence of a fatal transmissible malignancy known as devil facial tumour disease (DFTD). DFTD is unusual in that the infectious agent is the cancer cell itself. This chapter discusses the aetiology and pathogenesis of DFTD as well as the profound impact the spread of DFTD has had on the devil's conservation status. Strategies for managing DFTD and conserving the devil will be explored and the contribution of new sequencing technology to the field of conservation genetics and genomics will be examined with regard to the Tasmanian devil and DFTD. KeywordsTasmanian devil • Devil facial tumour disease • Wildlife disease • Conservation genetics • Genomics The Tasmanian Devil and the Emergence of DFTDThe Tasmanian devil (Sarcophilus harrisii), is the largest of the Dasyuridae, a speciose and morphologically diverse family of carnivorous marsupials that are represented in most terrestrial habitats in Australia and New Guinea (Crowther and Blacket, 2003). S. harrisii diverged in the mid Miocene, approximately 12.4 million years ago, and originally thrived on the Australian mainland (Krajewski et al., 2000). Tasmanian populations were separated from their mainland conspecifics after the formation of the Bass Strait 14,000 years ago (Lambeck and Chappell, 2001). Now the devil is confined to the island state; their extinction on mainland Australia

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Section: Disease Managementmentioning

confidence: 99%

Devil Facial Tumour Disease (DFTD): Using Genetics and Genomics to Investigate Infectious Disease in an Endangered Marsupial

Bender

2010

Marsupial Genetics and Genomics

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Assessment of a strain 19 brucellosis vaccination program in elk

et al. 2017

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Zoonotic diseases in wildlife present substantial challenges and risks to host populations, susceptible domestic livestock populations, and affected stakeholders. Brucellosis, a disease caused by the bacterium Brucella abortus, is endemic among elk (Cervus canadensis) attending winter feedgrounds and adjacent areas of western Wyoming, USA. To minimize transmission of brucellosis from elk to elk and elk to livestock, managers initiated a B. abortus strain 19 ballistic vaccination program in 1985. We used brucellosis prevalence and reproductive outcome (2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015) data collected from female elk attending feedgrounds to assess efficacy of the strain 19 program while controlling for potentially confounding factors such as site and age. From our generalized linear models, we found that seroprevalence of brucellosis was 1) not lower following inception of vaccination; 2) not inversely associated with proportion of juveniles vaccinated over time; 3) not inversely associated with additional yearlings and adults vaccinated over time; and 4) associated more with feeding end-date than proportion of juveniles vaccinated. Using vaginal implant transmitters in adult females that were seropositive for brucellosis, we found little effect of vaccination coverage at reducing reproductive failures (i.e., abortion or stillbirth). Because we found limited support for efficacy of the strain 19 program, we support research to develop an oral vaccine and suggest that continuing other spatio-temporal management actions will be most effective to minimize transmission of brucellosis and reduce dependency of elk on supplemental winter feeding. Ó 2017 The Wildlife Society.

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American Bison (Bison bison): A Rangeland Wildlife Continuum

Ranglack,

Plumb,

Rogers

2023

Rangeland Wildlife Ecology and Conservation

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American bison (Bison bison) are the largest extant land animal in North America and have an important history and contemporary role in modern conservation. Bison historically had the widest continental distribution of all native ungulates but now only function as wildlife under natural selection on < 1.2% of the original range. Bison as rangeland wildlife occur on an array of exclusive and overlapping governance jurisdictions (e.g., Federal, State, Provincial, County, and Tribes and First Nations), private not-for-profit conservation lands enterprises, zoo and education enterprises, and for-profit commodity production. The historical and prevailing relationships within and between these higher order sectors are very complex and often conflicting, yet each sector has invested tremendous effort and public and private resources to increase the total abundance of bison to present levels. Despite long-term public investment in wild bison conservation, the private sector has far out-stripped wild bison, resulting in a potentially divergent evolution trajectory towards species domestication. The primary ecosystem function of plains bison on rangelands is contributing to plant community heterogeneity through patchily distributed grazing events that create mosaics of grazing pressure. Additionally, bison exhibit a myriad of other roles in their environment through direct and indirect interactions. Perhaps more than with other rangeland wildlife species, genetics play an outsized role in current bison population management given historical bottlenecks and intentional cross breeding of bison and cattle. However, moving forward the interplay between population size, isolation, and genetic diversity is more important. Along the continuum of bison management there exist a wide variety of rangeland management techniques. However, as a wildlife species, the rangeland management practices associated with bison have generally focused on disturbance ecology with a more recent push to understand the impacts of bison grazing at scale. The question of scale is important given that every bison is behind a barrier, thus restricting their impacts on rangeland ecology and processes. Bison and cattle are considered by many to be potential competitors, due to large overlaps in diet and body size, and much research has focused on the ecological equivalence of the two species. While this is still not without controversy, bison and cattle are not incompatible when properly managed. Chronic infection of wild bison populations with diseases that can be transmitted to livestock and humans is an important factor affecting potential recovery of bison outside existing reserve boundaries. Climate change may represent the next major challenge to bison, as it is expected to directly affect bison through decreased forage and water availability and increased thermal stress. These threats, combined with the differences in bison management practices between sectors have led some to classify bison as moderately vulnerable to climate change, recommending the creation of a ‘bison coalition’ that could seek climate change adaptation solutions through shared stewardship. While much of the continental historical range is no longer available for bison restoration, there are exciting conservation opportunities that are finding voice through the vision of “Shared Stewardship” that embraces innovative collaboration to work together across jurisdictions and sectors to successfully address the scale, complexity, and ecological and cultural significance of wild bison.

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La vacunación en medicina de la conservación

Cited by 21 publications

References 55 publications

Devil Facial Tumour Disease (DFTD): Using Genetics and Genomics to Investigate Infectious Disease in an Endangered Marsupial

Devil Facial Tumour Disease (DFTD): Using Genetics and Genomics to Investigate Infectious Disease in an Endangered Marsupial

Assessment of a strain 19 brucellosis vaccination program in elk

American Bison (Bison bison): A Rangeland Wildlife Continuum

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