La tumeur de Buschke-Löwenstein

Kadouri, Youssef; Nouini, Yassine

doi:10.11604/pamj.2020.36.359.13292

Cited by 9 publications

(6 citation statements)

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“…BLT tends to occur in individuals in their forties. It has an estimated incidence of about 0.1% in the general population and a male-to-female ratio of 2.7:1 [28,32,33]. However, its precise incidence is unknown.…”

Section: Clinical Presentationmentioning

confidence: 99%

The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

Purzycka-Bohdan

Nowicki

Herms

et al. 2022

IJMS

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Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare disease of the anogenital region. BLT is considered a locally aggressive tumor of benign histological appearance, but with the potential for destructive growth and high recurrence rates. BLT development is strongly associated with infection with low-risk human papillomaviruses (HPVs), mostly HPV-6 and -11. Immunity to HPVs plays a crucial role in the natural control of various HPV-induced lesions. Large condyloma acuminata are frequently reported in patients with primary (e.g., DOCK8 or SPINK5 deficiencies) and secondary (e.g., AIDS, solid organ transplantation) immune defects. Individuals with extensive anogenital warts, including BLT in particular, should therefore be tested for inherited or acquired immunodeficiency. Research into the genetic basis of unexplained cases is warranted. An understanding of the etiology of BLT would lead to improvements in its management. This review focuses on the role of underlying HPV infections, and human genetic and immunological determinants of BLT.

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Section: Clinical Presentationmentioning

confidence: 99%

The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

Purzycka-Bohdan

Nowicki

Herms

et al. 2022

IJMS

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“…Furthermore, patients with HIV are more susceptible due to a local immunodeficiency that makes it difficult to eliminate HPV and this causes the progression of the lesions. 29,[30][31][32][33][34][35] Giant condyloma or Buschke-Löwenstein tumor often pose a diagnostic dilemma. These patients may present with nonspecific signs and symptoms, such as pain, hemorrhage, abscesses, and anogenital/ penile tumor, which presents as a slowly growing, exophytic, warty, cauliflower-shaped benign lesion; how was the development in our patient.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

OGIJ

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Background: Buschke-Löwenstein tumor is a presentation of condyloma acuminata; caused by human papillomavirus infection presenting as an exophytic, polypoid, cauliflower-like lesion; characterized by slow growth, local infiltration, contiguous tissue destruction; with a tendency to recurrence and produce fistulas or abscesses around the affected area. The most frequent location is the vulva, scrotum, penis, perineum and perianal region; Transmitted by sexual contact and more common in men, it is controversial whether it should be considered premalignant or a verrucous carcinoma; It does not present cellular atypia and a third can become malignant; recurrences are frequent. The risk factors are HPV, continuous irritation and poor hygiene of the genital area, phimosis, immunosuppression, smoking and drug addiction.Objective: review literature and case description.Case presentation: 45-year-old male with condylomatous lesion on the genitals of 4 months' duration, on the foreskin and ligament of the glans penis, and other minor lesions on the shaft of the penis; morbid obesity, uncontrolled type 2 diabetes mellitus. He is scheduled for circumcision and removal of the satellite lesions. Conclusion:Giant Buschke-Löwenstein condyloma is considered a low-grade squamous cell carcinoma, locally invasive, with aggressive behavior; Surgical treatment is the option.

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“…Correlación de subtipos de VPH y sus respectivas enfermedades [18]. La gran mayoría de la literatura revisada sugiere que el Gold standard es la cirugía con márgenes amplios [5,6,8,[19][20][21][22][23]. Se requiere de estudios de imagen preoperatorios para evaluar la extensión de la lesión y elegir la intervención correcta.…”

Section: Discussionunclassified

Tumor de Buschke – Löwenstein

Leone¹,

Carvajal²

2022

Rev. Oncol. Ecu.

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Introducción: El tumor de Buschke – Lowenstein (TBL) es enfermedad de transmisión sexual causada por el virus del papiloma humano (VPH), descrita como una forma intermedia entre un condiloma acuminado y un carcinoma de células escamosas. Afecta principalmente al área genital y anorrectal, posee capacidad de transformación maligna y una alta tasa de recurrencia. La cirugía es el tratamiento de primera línea. Caso clínico: Presentamos el caso de un paciente masculino de 27 años con lesiones verrucosas de crecimiento progresivo en el área inguinal y genital. Mediante la correlación clínico-patológica se llegó al diagnóstico de TBL. Tras discusión en comité multidisciplinario se declaró irresecable y se resolvió tratamiento con radioterapia, además vacunación terapéutica contra el VPH, tanto sistémica como intralesional. Conclusión: El TBL es localmente agresivo y de difícil tratamiento, por lo que la prevención contra el VPH es fundamental. La vacunación terapéutica en conjunto con la radioterapia ofreció mejoría clínica.

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La tumeur de Buschke-Löwenstein

Cited by 9 publications

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The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

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Tumor de Buschke – Löwenstein

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