La toracocentesis en la evaluación del cáncer de pulmón con derrame pleural

Díaz, E. Martín; Obrer, A. Arnau; Cebollada, Miguel Martorell; Armengod, A. Cantó

doi:10.1016/s0300-2896(02)75269-1

Cited by 13 publications

(2 citation statements)

References 26 publications

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“…In one series including 971 consecutive patients with lung cancer, Martin Diaz et al [22 ]found pleural effusion in 188 cases (19%), and only 72 of them (7%) were visible on chest X-ray films. The remaining 116 effusions were detected on CT or ultrasound examination, or were found only at thoracotomy.…”

Section: Indications For Thoracoscopymentioning

confidence: 99%

Medical Thoracoscopy

Rodríguez-Panadero¹

2008

Respiration

104

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As opposed to ‘video-assisted thoracoscopic surgery’ which requires general anesthesia, double-lumen tracheal intubation and single lung ventilation, medical thoracoscopy (or ‘pleuroscopy’) is frequently performed in the respiratory endoscopy suite using local anesthesia. It can be done by well-trained physicians, either pulmonologists or thoracic surgeons, and its main indication is related to diagnosis and treatment of pleural effusions. Also, pneumothorax can be managed in most cases using medical thoracoscopy. This article focuses in particular on technical aspects of medical thoracoscopy, including the selection and preparation of the patient, the choice of equipment, specific details of the procedure itself, and other technical details aimed at preventing complications.

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Section: Indications For Thoracoscopymentioning

confidence: 99%

Medical Thoracoscopy

Rodríguez-Panadero¹

2008

Respiration

104

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“…EGFR, ALK mutations). The limited tumour tissue and cell availability, the low and variable sensitivity of cytology (ranging from 43–91%) and the significant false-negative rate in the event of insufficient cell numbers from PE provided the impetus to investigate novel, complementary diagnostic markers 4 10 24 25 26 . The utilisation of cell-free DNA from blood samples as a surrogate for tumour biopsy to determine EGFR mutation status represents one such promising alternative that is currently evaluated clinically to assist the diagnosis of NSCLC 15 16 .…”

Section: Discussionmentioning

confidence: 99%

Lipidomic Profiling of Lung Pleural Effusion Identifies Unique Metabotype for EGFR Mutants in Non-Small Cell Lung Cancer

Yip

Basri

et al. 2016

Sci Rep

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Cytology and histology forms the cornerstone for the diagnosis of non-small cell lung cancer (NSCLC) but obtaining sufficient tumour cells or tissue biopsies for these tests remains a challenge. We investigate the lipidome of lung pleural effusion (PE) for unique metabolic signatures to discriminate benign versus malignant PE and EGFR versus non-EGFR malignant subgroups to identify novel diagnostic markers that is independent of tumour cell availability. Using liquid chromatography mass spectrometry, we profiled the lipidomes of the PE of 30 benign and 41 malignant cases with or without EGFR mutation. Unsupervised principal component analysis revealed distinctive differences between the lipidomes of benign and malignant PE as well as between EGFR mutants and non-EGFR mutants. Docosapentaenoic acid and Docosahexaenoic acid gave superior sensitivity and specificity for detecting NSCLC when used singly. Additionally, several 20- and 22- carbon polyunsaturated fatty acids and phospholipid species were significantly elevated in the EGFR mutants compared to non-EGFR mutants. A 7-lipid panel showed great promise in the stratification of EGFR from non-EGFR malignant PE. Our data revealed novel lipid candidate markers in the non-cellular fraction of PE that holds potential to aid the diagnosis of benign, EGFR mutation positive and negative NSCLC.

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Medical Thoracoscopy

Rodríguez-Panadero

2012

Interventions in Pulmonary Medicine

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La toracocentesis en la evaluación del cáncer de pulmón con derrame pleural

Cited by 13 publications

References 26 publications

Medical Thoracoscopy

Medical Thoracoscopy

Lipidomic Profiling of Lung Pleural Effusion Identifies Unique Metabotype for EGFR Mutants in Non-Small Cell Lung Cancer

Medical Thoracoscopy

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