La « synergie phages-antibiotiques »

Bacteriophages: Protagonists of a Post-Antibiotic Era

“…Through animal studies, it has been proven that these treatments have preventive action for bacteria resistance [ 45 ], for example, decreasing mutations that confer resistance to bacteria [ 46 ]. On the other hand, some of these antibiotics block the cellular cycle of bacteria, and as a result, bacterial cells undergo an increase in volume that facilitates the division of phages and their release at a faster pace [ 58 ]. Some studies have confirmed the effectiveness of this method, like the combination of phage SBW25φ2 with kanamycin antibiotic against P. fluorescens SBW25 [ 57 ].…”

Factors influencing horizontal gene transfer in the intestine

“…Recently, increasing evidence also indicated that SOS-inducing agents, particularly the SOS-inducing antibiotics, can trigger bacterial prophage induction, consequently enhancing transduction frequency (Comeau et al, 2007;Allen et al, 2011). For example, upon ciprofloxacin treatment, the genes associated with the SOS response as well as those for a viable bacteriophage were induced in Burkholderia thailandensis (Ulrich et al, 2013).…”

Temperate phage-antibiotic synergy eradicates bacteria through depletion of lysogens

“…One method of increasing the effectiveness of phages in general is through phage-antibiotic synergy (PAS) (Berryhill et al, 2021;Chaudhry et al, 2017;Comeau et al, 2007;Kamal and Dennis, 2015;Kebriaei et al, 2020;Kim et al, 2018;Nilsson, 2014;Rodriguez-Gonzalez et al, 2020;Tagliaferri et al, 2019) This phenomenon is characterized as the use of phages, in combination with antibiotics, to effectively reduce bacterial load and manage both phage and antibiotic resistance (Comeau et al, 2007). PAS has been studied since 2007 in virulent phages with antibiotics such as fluoroquinolones and b-lactams (Chaudhry et al, 2017;Comeau et al, 2007;Kamal and Dennis, 2015;Kim et al, 2018;Nilsson, 2014;Tagliaferri et al, 2019). Traditional PAS is proposed to be a result of antibiotic-induced cellular filamentation and resulting changes in phage replication, which help to increase phage production (Comeau et al, 2007;Kamal and Dennis, 2015;Kim et al, 2018).…”

“…PAS has been studied since 2007 in virulent phages with antibiotics such as fluoroquinolones and b-lactams (Chaudhry et al, 2017;Comeau et al, 2007;Kamal and Dennis, 2015;Kim et al, 2018;Nilsson, 2014;Tagliaferri et al, 2019). Traditional PAS is proposed to be a result of antibiotic-induced cellular filamentation and resulting changes in phage replication, which help to increase phage production (Comeau et al, 2007;Kamal and Dennis, 2015;Kim et al, 2018). These antibiotics are known to trigger the bacterial DNA repair pathway known as the SOS response, but curiously that pathway does not appear to be necessary for synergy (Comeau et al, 2007;Kim et al, 2018).…”

“…Traditional PAS is proposed to be a result of antibiotic-induced cellular filamentation and resulting changes in phage replication, which help to increase phage production (Comeau et al, 2007;Kamal and Dennis, 2015;Kim et al, 2018). These antibiotics are known to trigger the bacterial DNA repair pathway known as the SOS response, but curiously that pathway does not appear to be necessary for synergy (Comeau et al, 2007;Kim et al, 2018). This is of particular interest in the context of temperate phages given that this stress response canonically results in phage induction in many model lysogens (DeMarini and Lawrence, 1992;Goerke et al, 2006;Maiques et al, 2006).…”