La structure submicroscopique des elements basophiles cytoplasmiques dans le foie, le pancreas et les glandes salivaires

Waldenfels, Bernhard; Haguenau, F; Gautier, A; Oberling, C

doi:10.1007/bf00343816

Cited by 179 publications

(24 citation statements)

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“…There must be an intimate relationship between the sacs and the basophilic substances. This phenomenon is also pointed out by Dalton(7) and Bernhard (2) in the studies of another kinds of the tissues.…”

Section: Consideration On the Structure Of The Plasma Cellssupporting

confidence: 67%

“…The term used varied according to the variation of the authors, namely, lamelle (Dalton, 1950 (5)), Cytoplasmic double membranes (Sjostrand, 1953(33)), filamentous structures (Bernhard, 1952 (2)), ergastoplasmic sacs (Weiss, 1953)(45), endoplasmic reticulum (Porter, 1924) (Palade, 1956) (28,30) and intracytoplasmic sacs (Watanabe, 1953). We used the designation of "intracytoplasmic sacs" by Watanabe in this study.…”

Section: Consideration On the Structure Of The Plasma Cellsmentioning

confidence: 99%

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Electron-Microscopic Studies on Plasmacells and Lymphocytes in Human Palatine Tonsils by Ultrathin Slice Method

et al. 1960

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Section: Consideration On the Structure Of The Plasma Cellssupporting

confidence: 67%

Section: Consideration On the Structure Of The Plasma Cellsmentioning

confidence: 99%

Electron-Microscopic Studies on Plasmacells and Lymphocytes in Human Palatine Tonsils by Ultrathin Slice Method

et al. 1960

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“…In response to insulin, MAM-localized mTORC2 activates Akt proteins to phosphorylate PACS-2 Ser 437 , which increases ER-mitochondria contacts . Accordingly, by increasing MAM integrity, Akt-phosphorylated PACS-2 may increase lipogenesis, modulate ER-mitochondria Ca 2+ transfer and repress autophagy induction (Bernhard et al, 1952;Simmen et al, 2005;. By contrast, starvation triggers PACS-2 Ser 437 dephosphorylation, which would remodel MAMs to reduce lipogenesis but may increase ER-mitochondria Ca 2+ transfer and autophagy (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Mitochondria-associated membranes (MAMs) are ER-mitochondria contacts, which were discovered as lipogeneic platforms in liver that are responsive to feeding and starvation (Bernhard et al, 1952;Vance, 1990 Fig. 2.…”

Section: Introductionmentioning

confidence: 99%

Caught in the act – protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

Thomas

Aslan

Thomas

et al. 2017

Journal of Cell Science

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Vertebrate proteins that fulfill multiple and seemingly disparate functions are increasingly recognized as vital solutions to maintaining homeostasis in the face of the complex cell and tissue physiology of higher metazoans. However, the molecular adaptations that underpin this increased functionality remain elusive. In this Commentary, we review the PACS proteins -which first appeared in lower metazoans as protein traffic modulators and evolved in vertebrates to integrate cytoplasmic protein traffic and interorganellar communication with nuclear gene expression -as examples of protein adaptation 'caught in the act'. Vertebrate PACS-1 and PACS-2 increased their functional density and roles as metabolic switches by acquiring phosphorylation sites and nuclear trafficking signals within disordered regions of the proteins. These findings illustrate one mechanism by which vertebrates accommodate their complex cell physiology with a limited set of proteins. We will also highlight how pathogenic viruses exploit the PACS sorting pathways as well as recent studies on PACS genes with mutations or altered expression that result in diverse diseases. These discoveries suggest that investigation of the evolving PACS protein family provides a rich opportunity for insight into vertebrate cell and organ homeostasis.

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“…In 1952, Bernhard et al (15) observed enlarged nuclei and nucleoli and an increased amount of granular endoplasmic reticulum in rat liver 48 hours after partial hepatectomy. Later, Rouiller and Bernhard (16) reported an increase in the number and size of microbodies in rat liver.…”

Section: Introductionmentioning

confidence: 98%

A Fine Structure Study of Lipid in Mouse Liver Regenerating After Partial Hepatectomy

Trotter

1964

The Journal of Cell Biology

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The fine structure of liver 3½ to 72 hours after partial hepatectomy has been compared with that of liver from sham-operated animals; all animals were 60- to 90-day old male mice of the C3H strain. Numerous small bodies with diameters ranging from 300 to 1,000 A have been observed distributed randomly throughout the cytoplasm of the hepatic parenchymal cells at early intervals after partial hepatectomy. In material fixed in osmium tetroxide and embedded in methacrylate, they appear as uniformly electron-opaque bodies, but in permanganate-fixed liver, they display only a peripheral rim of electron-opaque material surrounding a clear core. Each of these cytoplasmic bodies appears to be located within a vesicle. A few of the opaque bodies are also present in sinusoids and in the spaces of Disse; these bodies are not located within vesicular structures. Fat droplets of various sizes are easily distinguished in regenerating liver; with the increase in number of these fat droplets at later postoperative intervals, there occurs a concomitant decrease in the number of cytoplasmic bodies. It is suggested that the cytoplasmic bodies contain some lipid component. Possible explanations of the origin, nature, and fate of the cytoplasmic bodies are discussed.

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La structure submicroscopique des elements basophiles cytoplasmiques dans le foie, le pancreas et les glandes salivaires

Cited by 179 publications

References 4 publications

Electron-Microscopic Studies on Plasmacells and Lymphocytes in Human Palatine Tonsils by Ultrathin Slice Method

Electron-Microscopic Studies on Plasmacells and Lymphocytes in Human Palatine Tonsils by Ultrathin Slice Method

Caught in the act – protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

A Fine Structure Study of Lipid in Mouse Liver Regenerating After Partial Hepatectomy

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