La schizophrénie à début précoce : caractéristiques cliniques et endophénotypiques

Missaoui, S.; Mechri, A.; Gaddour, N.; Slama, H.; Gaha, L.

doi:10.1016/j.amp.2005.09.026

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…These anomalies were also associated with age at onset of schizophrenia and not with clinical severity; more precisely, minor physical anomalies were more frequent in patients with early onset schizophrenia (i.e., with onset before age 18 years) compared to later onset patients [169]. Missaoui et al [170] confirm these previous studies. They reported that EOS patients, besides showing a greater severity of schizophrenia and negative symptomatology compared to individuals with later onset schizophrenia, had also more frequently minor physical and neurological abnormalities, including abnormalities of the face, hands, and ears.…”

Section: Minor Physical Anomaliessupporting

confidence: 53%

Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes

Priol

Denis

Boulanger

et al. 2021

IJMS

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Current research suggests that alterations in neurodevelopmental processes, involving gene X environment interactions during key stages of brain development (prenatal period and adolescence), are a major risk for schizophrenia. First, epidemiological studies supporting a genetic contribution to schizophrenia are presented in this article, including family, twin, and adoption studies. Then, an extensive literature review on genetic disorders associated with schizophrenia is reviewed. These epidemiological findings and clinical observations led researchers to conduct studies on genetic associations in schizophrenia, and more specifically on genomics (CNV: copy-number variant, and SNP: single nucleotide polymorphism). The main structural (CNV) and sequence (SNP) variants found in individuals with schizophrenia are reported here. Evidence of genetic contributions to schizophrenia and current knowledge on genetic syndromes associated with this psychiatric disorder highlight the importance of a clinical genetic examination to detect minor physical anomalies in individuals with ultra-high risk of schizophrenia. Several dysmorphic features have been described in schizophrenia, especially in early onset schizophrenia, and can be viewed as neurodevelopmental markers of vulnerability. Early detection of individuals with neurodevelopmental abnormalities is a fundamental issue to develop prevention and diagnostic strategies, therapeutic intervention and follow-up, and to ascertain better the underlying mechanisms involved in the pathophysiology of schizophrenia.

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Section: Minor Physical Anomaliessupporting

confidence: 53%

Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes

Priol

Denis

Boulanger

et al. 2021

IJMS

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“…According to a systematic review and meta-analysis, the overall prevalence of specific learning disabilities (SLD) in India was 8% (95% CI = 11 − 4) [6]. In a group of children with school failure, the prevalence of SLDs was 32%, which represents a general population prevalence of 6.4% [7].…”

Section: Introductionmentioning

confidence: 99%

Comparison of self-esteem and quality of life in 8-12-year-old children with ADHD with and without learning disorders

Massoodi,

Moudi,

Malekiamiri

et al. 2024

BMC Psychol

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Background Attention Deficit/Hyperactivity Disorder (ADHD) is one of the most common disorders in school-aged children. Learning disorder (LD) is also one of the most important psychiatric disorders in children, which can often be associated with ADHD. In this study, we sought to compare self-esteem and quality of life in 8 to 12-year-old children with attention deficit/hyperactivity disorder with and without co-occurring learning disorders in order to emphasize the importance of attention and diagnosis in children with ADHD. Method Among the 8- to 12-year-old outpatients referred to the child and adolescent psychiatry clinic of Omid Babol Clinic, 120 children aged 8 to 12 years with attention deficit/hyperactivity disorder whose disease was diagnosed by a child and adolescent psychiatry subspecialist. Among the tools used to collect information was the Colorado Learning Difficulties Questionnaire by Wilcott et al. (CLDQ), five-scale self-esteem test of Pepe et al. (1989) for children and quality-of-life questionnaire for 8–12-year-old children (PedsQL). Results This study investigated self-esteem and quality of life in children with ADHD (n = 120, 51.7% boys). Children with ADHD and learning disabilities reported significantly lower self-esteem and quality of life compared to those with ADHD alone. Conclusion Considering the relatively high probability of co-occurrence of ADHD and learning disorders, if one of them is diagnosed in a child, it is possible to look for other disorders in the child in order to avoid the more severe negative effects that this co-occurrence can have on the child by diagnosing it as soon as possible.

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Perception temporelle et schizophrénie : approche phénoménologique et neuropsychologique

et al. 2015

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La schizophrénie à début précoce : caractéristiques cliniques et endophénotypiques

Cited by 4 publications

References 18 publications

Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes

Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes

Comparison of self-esteem and quality of life in 8-12-year-old children with ADHD with and without learning disorders

Perception temporelle et schizophrénie : approche phénoménologique et neuropsychologique

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