La Región “Urabá Antioqueño-Cuencas altas de los ríos Sinú y San Jorge-Bajo Cauca Antioqueño”: “guarida” del paludismo colombiano

Carmona‐Fonseca, Jaime

doi:10.18273/revsal.v49n4-2017007

Cited by 17 publications

(16 citation statements)

References 44 publications

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“…Women were enrolled between September 2013 and May 2016 as part of a larger study in the municipality of Puerto Libertador, Department of Córdoba, in Northwestern Colombia (07°53′35′ N, 75°40″16″ W). This region has an estimated area of 43 506 km 2 , and a population of 2·5 million at risk of malaria . The region has stable malaria transmission intensity and is homogeneous in terms of eco‐epidemiology and malaria transmission.…”

Section: Methodsmentioning

confidence: 99%

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Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

Álvarez-Larrotta

Agudelo

Duque

et al. 2018

Clinical and Experimental Immunology

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Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological conditions for parasite transmission fluctuate. In chronic infections, the persistence of the antigenic stimulus changes the expression of immune mediators and promotes constant immune regulation, including increases in regulatory T cell populations. These alterations of the immune system could compromise the response to routine vaccination. This study aimed to evaluate the effect of submicroscopic plasmodial infection with P. falciparum and P. vivax during pregnancy on the immune response to the tetanus toxoid vaccine in Colombian women. Expression of different cytokines and mediators of immune regulation and levels of anti-tetanus toxoid (TT) immunoglobulin (Ig)G were quantified in pregnant women with and without submicroscopic plasmodial infection. The anti-TT IgG levels were significantly lower in the infected group compared with the uninfected group. The expression of interferon (IFN)-γ, tumour necrosis factor (TNF) and forkhead box protein 3 (FoxP3) was significantly higher in the infected group, while the expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and transforming growth factor (TGF)-β was lower in the group of infected. In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration.

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Section: Methodsmentioning

confidence: 99%

“…The region has a high malarial incidence, with a mean annual parasite index of 35·8 cases/1000 inhabitants. P. vivax and P. falciparum co‐exist, but P. vivax prevails (60–70% of the total) .…”

Section: Methodsmentioning

confidence: 99%

Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

Álvarez-Larrotta

Agudelo

Duque

et al. 2018

Clinical and Experimental Immunology

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“…Las mujeres y sus placentas fueron captadas en 2009 y 2016, en los hospitales de Puerto Libertador y Tierralta, municipios al sur del departamento de Córdoba, noroccidente de Colombia, en una región de alta endemicidad de malaria (21) . El sur de Córdoba, junto con Urabá Antioqueño y Bajo Cauca Antioqueño, conforman la región ecoepidemiológica que más casos de malaria genera anualmente en Colombia (21) .…”

Section: Diseño Y Población De Estudiounclassified

Malaria placentaria submicroscópica: histopatología y expresión de mediadores de procesos fisiológicos

López-Guzmán

Carmona‐Fonseca

2020

Rev Peru Med Exp Salud Publica

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Objetivos: Relacionar entre sí los eventos histopatológicos de malaria placentaria (MP), el comportamiento de células inmunitarias y la expresión de genes asociados a citoquinas, hipoxia, inflamación y angiogénesis en placentas con o sin infección plasmodial. Materiales y métodos: Diseño transversal, con tres grupos independientes. Las mujeres y sus placentas fueron captadas en 2009-2016, en los hospitales de Puerto Libertador y Tierralta, noroccidente de Colombia. El tamaño muestral se definió por conveniencia. El diagnóstico malárico se basó en PCR cuantitativa en tiempo real. Resultados: Se estudiaron 20 casos con MP por P. vivax (MP-V), 20 casos de MP por P. falciparum (MP-F) y 19 sin MP; 95% de los casos de MP son infección plasmodial placentaria submicroscópica (IPPS). Los tres grupos difieren en frecuencia y cantidad de eventos histopatológicos. Los mediadores de procesos fisiológicos presentaron diferencia significativa entre grupos, excepto IL-2, VEGF, VEGFR-1 y C5a. Conclusiones: Las placentas con infección difieren claramente de las no infectadas. P. vivax se comporta tan patógeno como P. falciparum. Se resalta la aproximación al abordaje integral del problema de MP. La infección plasmodial placentaria submicroscópica causa alteraciones tisulares y en mediadores fisiológicos como lo hace la infección microscópica, aunque probablemente en menor grado.

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“…In 2018, the country occupied the third position in the number of cases among the countries in Latin America [ 1 ], with 61,200 cases registered [ 2 ]; however, underestimation is presumed, with numerous cases not being reported to the surveillance system [ 3 ]. The Bajo Cauca region in NW Colombia, where this study was conducted, has historically registered among the highest number of malaria cases of the total in the country [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of land cover and landscape fragmentation on anopheline mosquito abundance and diversity in an important Colombian malaria endemic region

et al. 2020

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Landscape structure influences the distribution and abundance of anopheline mosquitoes and has an indirect impact on malaria transmission. This work aimed to determine the effect of land cover and landscape fragmentation on anopheline mosquito abundance and diversity in an important Colombian malaria endemic area, the Bajo Cauca region. Diversity indices were calculated for Anopheles mosquitoes collected in various localities of the region. Land cover types were characterized using orthorectified aerial photographs to estimate landscape metrics. The relationship between landscape fragmentation and species diversity was evaluated by regression analysis. The correlation between species abundance and land cover types was determined using canonical correspondence analyses. Results showed a statistically significant tendency for a lower diversity of the Anopheles community in landscapes with higher patch number, patch density and effective mesh size. For most species, there was evidence of a significant relationship between species abundance and land covers modified by anthropic activities which generate forest loss. These results indicate that activities that modify the landscape structure and land cover composition generate changes that affect the spatial distribution and composition of epidemiologically-important Anophele s species, which may impact malaria distribution in a region. This information is useful to guide control interventions that promote unfavorable landscapes for malaria vector propagation.

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La Región “Urabá Antioqueño-Cuencas altas de los ríos Sinú y San Jorge-Bajo Cauca Antioqueño”: “guarida” del paludismo colombiano

Cited by 17 publications

References 44 publications

Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

Malaria placentaria submicroscópica: histopatología y expresión de mediadores de procesos fisiológicos

Effect of land cover and landscape fragmentation on anopheline mosquito abundance and diversity in an important Colombian malaria endemic region

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