La polyveoline, nouvel indolosesquiterpene isole du polyalthia suaveolens, annonacees

In vitro cytotoxic, antileishmanial and antifungal activities of ethnopharmacologically selected Gabonese plants

“…They are also included in the treatment of rheumatism and toothache. Leaf and stem bark crude extracts have been shown to contain a wide range of chemical compounds including alkaloids (oliverine, oliveridine, polysuavine, polyalthine), triterpenes, aporphine alkaloids and indolosesquiterpene alkaloids (polyveoline, polyavolensin, polyavolensinol, polyavolensinone) and polyphenols (Okorie, 1980(Okorie, , 1981Cave et al, 1978;Hasan et al, 1982;Hocquemiller et al, 1981). Although they principally demonstrated filaricide (Onchocerca volvulus) activity (Titanji et al, 1990) mainly due to the presence of oliverine.…”

Biomimetic Cyclization of Epoxide Precursors of Indole Mono-, Sesqui- and Diterpene Alkaloids by Lewis Acids

“…There are some reports of the indole terpene alkaloids (polyveoline, 13) polyalthenol, 14) petromindole, 15) and emindole SA 16,17) as shown in Fig. 2) which have been assumed to be derived from 2-(10,11-epoxyfarnesyl)indole (1), 3-(10,11-epoxyfarnesyl)indole (2), 3-(10,11-epoxygeranylgeranyl)indole (5) and 3-(14,15-epoxygeranylgeranyl)indole (3) as respective biosynthetic intermediates; for example, polyveoline, which exhibits antiparasitic activity, has the 6.6.5-tricyclic framework cyclized from 1.…”

Chemical Constituents of Polyalthia nemoralis

“…120 species, is widely distributed in tropical and subtropical areas, with 17 species occurring in southern China [1]. Previous chemical studies on this genus have led to the isolation of diterpenes of the clerodane, halimane, and labdane types [2 -6], of triterpenes [7] [8], benzopyran derivatives [9], and several types of alkaloids, including aporphines [4] [10], indolosesquiterpenes [11] [12], benzylisoquinolines [13], tetrahydroprotoberberines [14] [15], morphinanedienones [16], and some azafluorene alkaloids [17] [18]. Many constituents exhibited cytotoxic [4], antimicrobial [19], antimalarial [20], and anti-HIV activities [21].…”