La phytovigilance : impératif médical et obligation légale

Lehmann, Hélène; Pabst, Jean-Yves

doi:10.1016/j.pharma.2015.06.004

Cited by 12 publications

(7 citation statements)

References 14 publications

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“…The plant extract and BHT (butylated hydroxytoluene) were tested with concentrations ranging from 1 to 14 mg/mL. Briefly, 150 µL of each concentration (1,2,4,6,8,10,12, and 14 mg/mL) were dropped in wells supplemented with 50 µL of previously prepared 1 mM DPPH solution. The prepared microplates were saved at an ambient temperature in darkness for 31 min.…”

Section: Dpph Assaymentioning

confidence: 99%

“…Plants have populated the planet for millions of years and have served humans and animals to meet their nutritional and medicinal requirements. Their uses have largely evolved with the discovery of their therapeutic properties [1]. Medicinal plants are defined as a vegetable that has at least a part (bark, leaves, roots, fruits) with medicinal properties [2].…”

Section: Introductionmentioning

confidence: 99%

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Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds

Bourhia

Bouothmany

Bakrim³

et al. 2021

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Background: Citrullus colocynthis L. (C. colocynthis) is commonly known as colocynth. It belongs to the family Cucurbitaceae that is frequently used in alternative medicine in the north of Africa. The aim of the study: the present research was undertaken to investigate the chemical composition, antioxidant, antiproliferative, and antibacterial potentials of C. colocynthis seed extract. Material and methods: the chemical composition of C. colocynthis seed organic extract was characterized using gas chromatography/mass spectrometry (GC-MS). The antioxidant property was carried out using both β-carotene bleaching and DPPH assays. The antibacterial effect was effectuated using the agar disc diffusion method. The antiproliferative activity vs. human colorectal adenocarcinoma cell line (HT-29) and human breast adenocarcinoma cell line (MDA MB 231) were carried by WST-1 test. The chemical analysis showed the presence of interesting potentially bioactive compounds. The studied plant extract exhibited antioxidant potential with IC50 value of 2. 22 mg/mL (β-carotene bleaching) and 8.98 ± 0.619 mg/mL (DPPH). Concerning the antiproliferative activity, the seed extract was effective in MDA-MB-231 and HT-29 cancer cells with IC50 values 86.89 ± 3.395 and 242.1 ± 17.9 μg/mL, respectively, whilst the extract of Citrullus colocynthis seeds was non-toxic in healthy human dermal fibroblasts. Regarding the antibacterial test, the extract was effective in Gram-positive bacteria only. Conclusion: The outcome of this research indicated that the extracts from C. colocynthis seeds may compose a promising source with interesting compounds that can be used to fight cancer, free radicals damage, and bacterial infections.

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Section: Dpph Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds

Bourhia

Bouothmany

Bakrim³

et al. 2021

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“…Phytovigilance 1 concerns domains from pharmacovigilance to nutrivigilance. In Europe, phytovigilance is supported by the European Medicinal Agency (EMA) at pharmacovigilance level and by the European Food Safety Agency (EFSA) at nutrivigilance level.…”

Section: Introductionmentioning

confidence: 99%

Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database

Pochet

Lechon

Lescrainier³

et al. 2022

Sci Rep

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Cancer patients could combine herbal treatments with their chemotherapy. We consulted VigiBase, a WHO database of individual case safety reports (ICSRs) which archives reports of suspected Adverse Drug Reactions (ADRs) when herbal products are used in conjunction with anti-cancer treatment. We focused on the possible interactions between antineoplastic (L01 ATC class) or hormone antagonists (L02B ATC class) with 10 commonly used herbs (pineapple, green tea, cannabis, black cohosh, turmeric, echinacea, St John’s wort, milk thistle and ginger) to compare ADRs described in ICSRs with the literature. A total of 1057 ICSRs were extracted from the database but only 134 were complete enough (or did not concern too many therapeutic lines) to keep them for analysis. Finally, 51 rationalizable ICSRs could be explained, which led us to propose a pharmacokinetic or pharmacodynamic interaction mechanism. Reports concerned more frequently women and half of the rationalizable ICSRs involved Viscum album and Silybum marianum. 5% of the ADRs described could have been avoided if clinicians had had access to the published information. It is also important to note that in 8% of the cases, the ADRs observed were life threatening. Phytovigilance should thus be considered more by health care professionals to best treat cancer patients and for better integrative care.

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“…It is essential to develop reliable information on the safety of herbal medicines [7]. Becoming necessary due to risks of toxicity (acute or chronic) or risks of drug interactions (of pharmacokinetic or pharmacodynamic nature), as regards interactions between several associated plants, phytovigilance also represents a legal obligation [8]. Several issues related to how herbal medicines are named, perceived, obtained and used [9].…”

Section: Introductionmentioning

confidence: 99%

Overview on pharmacovigilance of nephrotoxic herbal medicines used worldwide

2021

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Materials and methods Search strategyElectronic literature searches were conducted in Mai 2020 to identify case reports of nephrotoxicity associated with herbal medicines use in the last two decade. The scientific resources including PubMed, Scopus, and Science direct were searched using key words such as: 'case report', 'Renal side effect', 'adverse effects', 'Nephrotoxicity', 'Risk', 'Herbal Medicine', 'kidney disease'. The spectrum of herbal induced kidney injuries included kidney stones, nephritis, nephrotic syndrome, necrosis, acute kidney injury, chronic kidney disease, and death. English articles were the primary focus, but some reports in other languages were considered. Inclusion and exclusion criteriaEligible studies had to fulfil the following criteria: Included studies were case reports of nephrotoxicity associated to herbs use worldwide between 2000 and 2020.Exclusion criteria: Case reports were excluded if they involved mushrooms, poisonous plants, self-harm, excessive doses (except vitamins/minerals), drug-herbal interactions and commercial dietary supplement.

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La phytovigilance : impératif médical et obligation légale

Cited by 12 publications

References 14 publications

Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds

Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds

Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database

Overview on pharmacovigilance of nephrotoxic herbal medicines used worldwide

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