La pharmacorésistance aux psychotropes chez l’enfant et l’adolescent : recherche d’anomalies pharmacogénétiques du cytochrome P450 2D6

David, A.; Fernandez, Arnaud; Ménard, Marie-Line; Dor, E.; Leali, G.; Maria, F.; Cruzel, Coralie; Askénazy, Florence; Verstuyft, Céline; Thümmler, Susanne

doi:10.1016/j.encep.2020.09.010

Cited by 1 publication

(1 citation statement)

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“…Therefore, genetic pro ling in drug metabolism may help guide clinical treatment in psychiatric diseases (13). However, additional evidence is needed to con rm the role of the ultra-rapid phenotype of CYP genes in the treatment of psychotropic drugs, and pharmacogenetic analysis in drug transport and action may also play an important role (14). In addition, age and body weight are other factors involved in the safety and e cacy of APs by in uencing pharmacokinetics (15,16).…”

Section: Introductionmentioning

confidence: 99%

Case Report: CYP1A2 Ultra-Rapid Metabolizer in schizophrenia with multiple overdose antipsychotics

Yang,

Cao,

et al. 2023

Preprint

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Background Liver cytochrome P450 (CYP450) enzymes play an important role in metabolizing antipsychotics (APs) and other drugs. Excessive use of drugs can impair liver function and even other organs, thus causing several adverse effects. In addition, metabolizer types of CYP450 enzymes may influence the therapeutic effects and drug reactions. Case presentation In this case, we described a patient with schizophrenia who took overdose of multiple kinds of APs and other herbal preparations together for nearly two years. However, poor treatment effects and minor side effects of APs were presented in this patient. After pharmacogenomic examination, we found this patient was a CYP1A2 ultra-rapid metabolizer. Conclusions CYP1A2 ultra-rapid metabolizer may explain part of the poor therapeutic effects and small adverse effects in this case who took multiple kinds of overdose drugs. Many factors may be involved in the rare presentations in this patient.

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Section: Introductionmentioning

confidence: 99%