La Non-Alcoholic Fatty Liver Disease, una patologia epatica di interesse endocrinologico

Gangitano, Elena; Corradini, Stefano Ginanni; Lubrano, Carla; Gnessi, Lucio

doi:10.1007/s40619-021-00955-9

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…On the other hand, GH is typically elevated at the onset of sleep, with the highest levels during SWS and starts to decline during the fourth decade of life [158]. Growth hormone deficiency has been linked with an increase in fat accumulation in adults [159,160], and some studies reported an increase in hepatic steatosis, even though the results are not univocal [161].…”

Section: Key Molecules Linking Metabolism and Sleep In Animals And Hu...mentioning

confidence: 99%

Weight Loss and Sleep, Current Evidence in Animal Models and Humans

et al. 2023

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Sleep is a vital process essential for survival. The trend of reduction in the time dedicated to sleep has increased in industrialized countries, together with the dramatic increase in the prevalence of obesity and diabetes. Short sleep may increase the risk of obesity, diabetes and cardiovascular disease, and on the other hand, obesity is associated with sleep disorders, such as obstructive apnea disease, insomnia and excessive daytime sleepiness. Sleep and metabolic disorders are linked; therefore, identifying the physiological and molecular pathways involved in sleep regulation and metabolic homeostasis can play a major role in ameliorating the metabolic health of the individual. Approaches aimed at reducing body weight could provide benefits for both cardiometabolic risk and sleep quality, which indirectly, in turn, may determine an amelioration of the cardiometabolic phenotype of individuals. We revised the literature on weight loss and sleep, focusing on the mechanisms and the molecules that may subtend this relationship in humans as in animal models.

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Section: Key Molecules Linking Metabolism and Sleep In Animals And Hu...mentioning

confidence: 99%

Weight Loss and Sleep, Current Evidence in Animal Models and Humans

et al. 2023

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“…Metabolic disturbances, included diabetes and non-alcoholic liver disease, are strictly connected among each other, and they similarly interact with lack of sleep. Metabolic disturbances are often associated to hormonal imbalances, which may play a role in their development, in a complex relationship of mutual influence (33)(34)(35)(36). Some hormones may be involved in the association between metabolic disturbances and reduced sleep.…”

Section: Introduction 1sleep Disturbances and Metabolic Disturbances:...mentioning

confidence: 99%

The interplay between macronutrients and sleep: focus on circadian and homeostatic processes

Gangitano,

Baxter,

Voronkov

et al. 2023

Front. Nutr.

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Sleep disturbances are an emerging risk factor for metabolic diseases, for which the burden is particularly worrying worldwide. The importance of sleep for metabolic health is being increasingly recognized, and not only the amount of sleep plays an important role, but also its quality. In this review, we studied the evidence in the literature on macronutrients and their influence on sleep, focusing on the mechanisms that may lay behind this interaction. In particular, we focused on the effects of macronutrients on circadian and homeostatic processes of sleep in preclinical models, and reviewed the evidence of clinical studies in humans. Given the importance of sleep for health, and the role of circadian biology in healthy sleep, it is important to understand how macronutrients regulate circadian clocks and sleep homeostasis.

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Nonalcoholic fatty liver disease and diabetes

Bellini¹,

Urciuoli²,

Gaudio³

et al. 2022

WJD

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Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world and represents a clinical-histopathologic entity where the steatosis component may vary in degree and may or may not have fibrotic progression. The key concept of NAFLD pathogenesis is excessive triglyceride hepatic accumulation because of an imbalance between free fatty acid influx and efflux. Strong epidemiological, biochemical, and therapeutic evidence supports the premise that the primary pathophysiological derangement in most patients with NAFLD is insulin resistance; thus the association between diabetes and NAFLD is widely recognized in the literature. Since NAFLD is the hepatic manifestation of a metabolic disease, it is also associated with a higher cardio-vascular risk. Conventional B-mode ultrasound is widely adopted as a first-line imaging modality for hepatic steatosis, although magnetic resonance imaging represents the gold standard noninvasive modality for quantifying the amount of fat in these patients. Treatment of NAFLD patients depends on the disease severity, ranging from a more benign condition of nonalcoholic fatty liver to nonalcoholic steatohepatitis. Abstinence from alcohol, a Mediterranean diet, and modification of risk factors are recommended for patients suffering from NAFLD to avoid major cardiovascular events, as per all diabetic patients. In addition, weight loss induced by bariatric surgery seems to also be effective in improving liver features, together with the benefits for diabetes control or resolution, dyslipidemia, and hypertension. Finally, liver transplantation represents the ultimate treatment for severe nonalcoholic fatty liver disease and is growing rapidly as a main indication in Western countries. This review offers a comprehensive multidisciplinary approach to NAFLD, highlighting its connection with diabetes.

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La Non-Alcoholic Fatty Liver Disease, una patologia epatica di interesse endocrinologico

Cited by 3 publications

References 29 publications

Weight Loss and Sleep, Current Evidence in Animal Models and Humans

Weight Loss and Sleep, Current Evidence in Animal Models and Humans

The interplay between macronutrients and sleep: focus on circadian and homeostatic processes

Nonalcoholic fatty liver disease and diabetes

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