La mort subite au cours d’une activité sportive en Tunisie : à propos d’une série autopsique de 32 cas

Allouche, Mohamed; Boudriga, N.; Ahmed, Habib Ben; Banasr, Ahmed; Gloulou, F.; Zhioua, M.; Bouhajja, B.; Baccar, H.; Hamdoun, Moncef

doi:10.1016/j.ancard.2012.08.030

Cited by 20 publications

(10 citation statements)

References 25 publications

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“…In the current study, most deaths occurred at rest (or minimal daily activity). This result is consistent with the majority of studies published in the literature [8,21,22,27]. This predominance could be explained by the fact that in the indeterminate forms of death, and hypertrophic cardiomyopathy, the death is rather the consequence of a rhythm disorder whose occurrence is often at rest or during sleep.…”

Section: Discussionsupporting

confidence: 92%

“…It is recognized that regular physical exercise requires long-term cardiovascular protection [20]. Death during physical activity often occurs during the recovery period [21]. In a British study, only 20% of hypertrophic cardiomyopathy patients were diagnosed during life, underscoring how often the disease is not identi ed during life, and sudden cardiac death can be the rst manifestation.…”

Section: Discussionmentioning

confidence: 99%

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Sudden death in the young adult: A Tunisian autopsy-based series

Saadi

Jomâa

Hadj

et al. 2020

Preprint

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Background: We aim to study the profile, and pathological characteristics of sudden death in young in purpose of recommendations for prevention. Methods: We performed a retrospective cohort study using autopsy data from the Department of Forensic Medicine of Monastir (Tunisia). A review of all autopsies performed for 28 years was done (August 1990 to December 2018). In each case, clinical information, and circumstances of death were obtained. A complete forensic autopsy and histological, and toxicological investigations were performed. We have included all sudden death in persons aged between 18 years and 35 years.Results: We collected 137 cases of sudden death during the studied period. The mean age of the studied population was 26.47 years. Almost 72% deaths were classified as cardiac death, and was due to ischemic heart disease in 32.32%. Sudden death was attributed to a pleuropulmonary cause in 7.4%, an abdominal cause in 6%, and from a neurological origin in 4.5%. The cause of sudden death in this group was not established by 9.5%.Conclusion: In this series, sudden death in young adults occurs mainly in a smoking male, aged between 18 and 24 years old, occurring at rest, in the morning, and early in the week. It is more common, especially in summer. Sudden death is most often the first manifestation of pathologies, especially unsuspected heart diseases. The predominance of cardiovascular causes is the common denominator of almost all studies reported in the literature. Our findings suggest that prevention of sudden death among young adults under the age of 35 years should also focus on evaluation for causes not associated with structural heart disease.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Sudden death in the young adult: A Tunisian autopsy-based series

Saadi

Jomâa

Hadj

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In our study, most deaths occurred at rest (or minimal daily activity). This result is consistent with the majority of studies published in the literature [8,[19][20][21]. This predominance could be explained by the fact that in the indeterminate forms of death, and hypertrophic cardiomyopathy, the death is rather the consequence of a rhythm disorder whose occurrence is often at rest or during sleep.…”

Section: Discussionsupporting

confidence: 92%

Sudden death in the young adult: An autopsy-based series

Saadi

Jomâa

Hadj

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: We aim to study the profile, and pathological characteristics of sudden death in young in purpose of recommendations for prevention. Methods: We performed a retrospective cohort study using autopsy data from the Department of Forensic Medicine of Monastir (Tunisia). A review of all autopsies performed for 28 years was done. In each case, clinical information, and circumstances of death were obtained. A complete forensic autopsy and histological, and toxicological investigations were performed. We have included all sudden death in persons aged between 18 years and 35 years.Results: We collected 137 cases of sudden death during the studied period. The mean age of the studied population was 26.47 years. Almost 72% deaths were classified as cardiac death, and was due to ischemic heart disease in 32.32%. Sudden death was attributed to a pleuropulmonary cause in 7.4%, an abdominal cause in 6%, and from a neurological origin in 4.5%. The cause of sudden death in this group was not established by 9.5%.Conclusion: There are several potential causes of sudden unexplained death such as structural abnormalities, ion channel abnormalities. Unexplained deaths, presumed to result from sudden primary arrhythmogenic causes, occur in a young adult with structurally normal hearts. That underlying disease-causing genetic defects may be involved has clinical implications for family members. Our findings suggest that prevention of sudden death among young adults under the age of 35 years should also focus on evaluation for causes not associated with structural heart disease.

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“…However, the clinical profile of the disease in Africa has received little attention, with reports limited to Egypt and South Africa. 2 , 3 In a recently published series of autopsy findings on juvenile sudden cardiac victims in Tunisia, HCM was diagnosed in 9 of 32 individuals (33%), 4 suggesting an important burden of disease among young individuals in a country that is home to over 10 million inhabitants with complex ethnic background. The genetic basis of HCM in Tunisia, however, has not been previously explored.…”

mentioning

confidence: 99%

Genetic profile of hypertrophic cardiomyopathy in Tunisia: Is it different?

Jaafar

Girolami

Zairi

et al. 2015

Global Cardiology Science and Practice

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We recently performed next generation sequencing (NGS) genetic screening in 11 consecutive and unrelated Tunisian HCM probands seen at Habib Thameur Hospital in Tunis in the first 6 months of 2014, as part of a cooperative study between our Institutions. The clinical diagnosis of HCM was made according to standard criteria. Using the Illumina platform, a panel of 12 genes was analyzed including myosin binding protein C (MYBPC3), beta-myosin heavy chain (MYH7), regulatory and essential light chains (MYL2 and MYL3), troponin-T (TNNT2), troponin-I (TNNI3), troponin-C (TNNC1), alpha-tropomyosin (TPM1), alpha-actin (ACTC1), alpha-actinin-2 (ACTN2) as well as alfa-galactosidase (GLA), 5′-AMP-activated protein (PKRAG2), transthyretin (TTR) and lysosomal-associated membrane protein-2 (LAMP2) for exclusion of phenocopies. Our preliminary data, despite limitations inherent to the small sample size, suggest that HCM in Tunisia may have a peculiar genetic background which privileges rare genes overs the classic HCM-associated MHY7 and MYBPC3 genes.

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La mort subite au cours d’une activité sportive en Tunisie : à propos d’une série autopsique de 32 cas

Cited by 20 publications

References 25 publications

Sudden death in the young adult: A Tunisian autopsy-based series

Sudden death in the young adult: A Tunisian autopsy-based series

Sudden death in the young adult: An autopsy-based series

Genetic profile of hypertrophic cardiomyopathy in Tunisia: Is it different?

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