La mitochondrie

Bandiera, Simonetta; Barrey, Éric; Ernoult‐Lange, Michèle; Gidrol, Xavier; Henrion‐Caude, Alexandra; Huang, Lue; Saint-Auret, Gaëlle; Weil, Dominique

doi:10.1051/medsci/2012281008

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Identification of specific targets can be done by RNA interference (RNAi) [32–34]. As a powerful tool to suppress gene expression in mammalian cells, the RNAi can be directed against pancreatic cancer through various pathways, including the inhibition of overexpressed oncogenes, suppression of tumor growth, metastasis, and enhancement of apoptosis [35, 36]. …”

Section: Discussionmentioning

confidence: 99%

Potential Effects of Mina53 on Tumor Growth in Human Pancreatic Cancer

Tan

Dong

Zhang

et al. 2014

Cell Biochem Biophys

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Myc-induced nuclear antigen (Mina53) is a protein with a molecular weight of 53 kDa expression of which is induced by c-Myc. Increased expression of Mina53 is documented in some human carcinomas. In this study, we found markedly increased Mina53 expression in pancreatic cancer tissue specimens. This expression did not correlate with clinicopathological characteristics, such as sex, age, and presence of distant metastasis. However, there was a statistically significant association with histological differentiation, TNM stage, and lymph node metastases. To study functional role of Mina53, we silenced its expression by siRNA in PANC-1 cells. These cells were arrested in the G2/M phase, and apoptosis rates were increased. In conclusion, increased expression of Mina53 may play an important role in the development of human pancreatic cancer. Mina53 can be used as a marker for pancreatic cancer and may potentially be exploited as a target for treatment of pancreatic cancer.

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