The study was conducted to determine level of some essential minerals (zinc Zn and iron Fe) in patients infected with Leishmania tropica/ major. study was conducted in Sharqat district, during September 2018 till April 2019, included 61 patients with leishmaniasis diagnosed clinically by dermatologist and confirmed by microscopic examination of lesion material. The samples were divided into eight age groups (2 ≤, 3-6, 7-12, 13-22, 23-32, 33-42, 43-52 and 53 ≥ years). Also, 101 healthy people are as a control group. The level of Zn and Fe in serum are measured by using automated spectrophotometer. The study determined a significant decrease P < 0.01 in Zn and Fe level in both genders for all age groups when compared with control groups.