La maladie de Hodgkin chez les patients atteints du virus de l'immunodéficience humaine

Costello, Régis T.; Heuberger, Laurence; Petit, Nathalie; Olive, Daniel; Gastaut, J. A.

doi:10.1016/s0248-8663(99)80023-x

Cited by 4 publications

(1 citation statement)

References 49 publications

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“…central nervous system lymphoma occurs in 15-25% of cases (88)(89)(90). Apart from other lymphomas, cases of HD occurrence upon HIV-infection have been reported, as well as of T-cell lymphomas in 5 10% of cases (83,(91)(92)(93)(94). HIV-associated T-cell lymphomas include lymphoblastic lymphoma, PTCL, ALCL and cutaneous T-cell lymphoma.…”

Section: Hiv/sivmentioning

confidence: 99%

Virus-associated lymphomagenesis

Tarantul

2006

Int. J Biomed Sci.

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At least 2 billion people are affected by viral infections worldwide. The infections induce a lot of various human diseases and are one of the main causes of human mortality. In particular, they can lead to development of various human cancers. Up to 15-20% of human cancer incidence can be attributed to viruses. Although viral infections are very common in the general population, only few of them result in clinically relevant lesions. Certain associations between virus infections and malignancy are strong and irrefutable, the others are still speculative. The criteria most often used for determining the causality are the consistence of the association, either epidemiologic or at the molecular level, and oncogenicity of viruses or particular viral genes in animal models or cell cultures. Due to some ambiguity of such a determination, it is instructive to consider by specific cases what evidence is generally accepted as sufficient to establish a causal relation between virus and cancer. Lymphomas are one of the best studied cancer types closely associated with a small but definite range of viruses. Numerous data show a close interrelation between lymphomagenesis and infection by such viruses as Kaposi's sarcoma herpesvirus (KSHV), Epstein-Barr virus (EBV), hepatitis C virus (HCV), human T-cell leukemia virus (HTLV), and human immunodeficiency virus (HIV). For instance, experiments on monkeys artificially infected with viruses and data on anti-cancer effect of specific antiviral preparations strongly suggest the involvement of viruses in lymphoma development. The present review is devoted to the association of different viruses with human lymphomas and to viral genes potentially involved in the neoplastic process. The recognition of virus involvement in lymphomagenesis may facilitate new strategies for cancer therapy, diagnosis and screening and can lead to a reduction in the number of individuals at risk of disease.

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Section: Hiv/sivmentioning

confidence: 99%

Virus-associated lymphomagenesis

Tarantul

2006

Int. J Biomed Sci.

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Advanced Hodgkin's disease in a pregnant HIV seropositive woman: Favorable mother and baby outcome following combined anticancer and antiretroviral therapy

et al. 2000

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We describe a 33 y/o HIV(+) woman who developed advanced Hodgkin's disease (HD) during the 2nd trimester of her pregnancy. Combination chemotherapy and antiretroviral treatment along with opportunistic infection prophylaxis were administered. At term, while in partial remission, she delivered by a Caesarian section a healthy baby, PCR-negative for HIV. A complete remission was later achieved upon completion of the chemotherapy regimen. Since both the incidence of HD and the proportion of young women among the HIV(+) individuals are increasing, it seems important to recognize that successful completion of pregnancy with no deterioration of accepted surrogate parameters of HIV disease progression is achievable in a carefully treated HIV(+) pregnant woman with advanced HD.

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