La maladie de Eales

Errera, Marie‐Hélène; Pratas, Ana; Goldschmidt, Pablo; Sédira, Neila; Sahel, José‐Alain; Benesty, Jonathan

doi:10.1016/j.jfo.2016.03.001

Cited by 12 publications

(9 citation statements)

References 38 publications

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“…Immunologic mechanisms, mainly cell-mediated, have been proposed for Eales' etiology [ 3 , 5 ]. From the various causes suggested, Mycobacterium tuberculosis is the most common reported.…”

Section: Discussionmentioning

confidence: 99%

“…Eales' disease is a primary idiopathic peripheral obstructive retinal vasculopathy, reported in 1880 by Henry Eales for the first time [ 1 ]. A relation to ocular inflammation was described few years later [ 2 , 3 ]. Healthy young men are the most affected by this disease, which is more prevalent in India and the Middle East [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Different therapeutic approaches are suggested for Eales' disease, depending on its clinical stage [ 3 , 5 ]. The typical retinal vasculitis usually requires treatment with systemic steroids in combination with complete antituberculosis therapy for a minimal period of 9 months.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Eales’ Disease: When the Rare Sounds Frequent

Lopes

Brízido

Reis

et al. 2021

Case Reports in Ophthalmological Medicine

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Eales’ disease is a peripheral occlusive retinal phlebitis, with an unclear pathogenesis. The classic association with hypersensitivity to Mycobacterium tuberculosis protein infers that immunologic disturbance may be involved. Here, we described three cases of Eales’ disease. All patients are Caucasian men aged 27-58 years and presented with vitreous hemorrhage and/or peripheral venous vasculitis. Tuberculin skin sensitive test (Mantoux screening test) and interferon-gamma release assay (IGRA) were positive in all patients. Therapeutic approach included antituberculosis therapy and systemic steroids, associated or not to immunosuppressive therapy, and retinal scatter photocoagulation in all cases. Antivascular endothelial grow factor (VEGF) intravitreal injections were also required in two cases. Since various retinal diseases can resemble this presentation, Eales’ disease is considered a diagnosis of exclusion. Early diagnosis and appropriate therapeutic approach are both essential to accomplish disease control and reduce ophthalmologic complications.

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“…Immunologic mechanisms, mainly cell-mediated, have been proposed for Eales' etiology [ 3 , 5 ]. From the various causes suggested, Mycobacterium tuberculosis is the most common reported.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Eales’ Disease: When the Rare Sounds Frequent

Lopes

Brízido

Reis

et al. 2021

Case Reports in Ophthalmological Medicine

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“…Therefore, we hypothesized that the retinal microcirculation abnormalities in POI patients were associated with chronic and lower levels of E2. So far, there was no literature supporting the nding that the protective effect of estrogen on cardiovascular system is mainly through the in uence of coagulation and brinolysis system, in ammatory factors and vascular endothelial cells [27][28][29][30], which may re ect that microvascular injury is caused by POI and can be identi ed by retinal bifurcation coe cient. Since biological effects are considered to be more complex, we explored the interaction between retinal features.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Retinal Image Associated with Premature Ovarian Insufficiency

Tan

Ning

et al. 2021

SSRN Journal

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Purpose To establish a prediction model for premature ovarian insu ciency (POI) identi cation.Methods A total of 78 women with spontaneous POI and 48 healthy women were recruited from the A liated Shenzhen Maternity & Child Healthcare Hospital in the study. Retinal characteristics were analyzed using an automated retinal image analysis system. Binary logistic regression was used to identify POI cases and develop predictive models.Results Compared to the normal group, the POI group had larger central retinal artery equivalent (CRAE) (P=0.006), central retinal vein equivalent (CRVE) (P=0.001), index of venules asymmetry (Vasym) (P=0.000); larger bifurcation angles of arterioles (Aangle) (P=0.001), bifurcation coe cient of venule (BCV) (P=0.001) and more obvious arteriovenous nipping (Nipping) (P=0.005), but lower arteriole-tovenule ratio (AVR) (P=0.012). In the POI group, the odds ratio (OR) of Vasym was 6.72e-32 (95% C.I. 4.62e-49-9.79e-15, P=0.000), the OR of BCV was 5.66e-20 (95% C.I. 1.93e-34-.0000, P=5.66e-20) and the OR of Nipping was 6.65e-06 (95% C.I. 6.33e-10-.0698, P=0.012). Moreover, the area under the ROC curve for the binary logistic regression with retinal characteristics was 0.8582, and the tting degree of regression models was 60.48% (Prob> chi-square = 0.6048). ConclusionThis study demonstrated that retinal image analysis can provide useful information for POI identi cation and certain characteristics may help with early clinical diagnosis of POI.

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“…The disease is very common in young adults, especially habitants of sub-continent. 2 ED has overlapping stages of retinal vasculitis, non-perfusion, neovascularization, Vitreous Hemorrhage (VH) and Tractional Retinal Detachment (TRD). Most of the patients present with sudden visual loss due to VH, with bilateral and asymmetrical disease.…”

Section: Introductionmentioning

confidence: 99%

Role of intravitreal bevacizumab in management of Eale’s Disease

Mehboob¹,

Tahir²,

Batool³

2018

Pak J Med Sci

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Objective:To investigate the role of Intravitreal Bevacizumab (IVB), in preventing vitreo-retinal complications in patients of Eale’s Disease (ED).Methods:This randomized control trial was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from May 2015 to December 2016. A total of 52 eyes of 26 patients, diagnosed with stage I or II of ED were randomly divided in two groups. Group A received monthly injections of IVB for 3 months, with steroids and laser photocoagulation. Group B received only steroids and laser treatment. Patients were followed for three months, and were analyzed for different clinical parameters.Results:Mean age of study population was 28.5±2.64 years. Difference in frequency of patients requiring PPV and showing regression in neovascularization was statistically significant between both groups (p=0.005 for both). However, difference in frequency of patients showing progression in stage of ED, regression of vasculitis and best corrected visual acuity at 12 weeks between two groups was not statistically significant (p= 0.012, 0.579, 0.046 respectively).Conclusion:Intravitreal Bevacizumab injection, given monthly in patients of ED results in significantly more regression in neovascularization, and less requirement for PPV, as compared to those receiving standard steroids and laser photocoagulation treatment.

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La maladie de Eales

Cited by 12 publications

References 38 publications

Eales’ Disease: When the Rare Sounds Frequent

Eales’ Disease: When the Rare Sounds Frequent

Characteristics of Retinal Image Associated with Premature Ovarian Insufficiency

Role of intravitreal bevacizumab in management of Eale’s Disease

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