La lutte antituberculeuse dans le monde

Kamel, A. El; Joobeur, S.; Skhiri, N.; Mhamed, S. Cheikh; Mribah, H.; Rouatbi, N.

doi:10.1016/j.pneumo.2014.03.004

Cited by 8 publications

(7 citation statements)

References 17 publications

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“…Elle était associée aux formes graves de la tuberculose (Tuberculose extrapulmonaire) et à une augmentation du taux de mortalité chez les tuberculeux; ce qui rejoint les résultats des études antérieures [6, 7]. Par ailleurs, les indicateurs de la co-infection recherchés dans cette étude rejoignent les cibles du plan mondial Halte à la tuberculose 2011-2015 [8], sauf pour ce qui est du pourcentage des patients ayant reçu un traitement antirétroviral qui était de 93,9% au lieu de 100%. Les patients n'ayant pas reçu de traitement antirétroviral sont décédés dans les deux semaines après le début du traitement antituberculeux.…”

Section: Aux Editeurs Du Journal Panafricain De Médecineunclassified

Co-infection VIH chez les tuberculeux suivis au service des maladies infectieuses du CHU Ibn Rochd-Casablanca

Kettani¹,

Jebbar²,

Takourt³

et al. 2018

Pan Afr Med J

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L'objectif du travail est de déterminer la prévalence de l'infection par le VIH chez les tuberculeux hospitalisés au service des maladies infectieuses du CHU Ibn Rochd-Casablanca et de chercher les facteurs associés à la co-infection Tuberculose-VIH. Nous avons mené une étude transversale rétrospective menée en Novembre 2016, en se basant sur l'exploitation de la base de données du service des maladies infectieuses, des laboratoires de microbiologie et d'immunologie du CHU Ibn Rochd. Etaient inclus les patients ayant une tuberculose confirmée par culture positive sur milieu de Lowenstein Jensen et une infection à VIH confirmée par Western Blot entre Janvier 2013 et Décembre 2015. Au cours de la période de l'étude, 117 cas de tuberculose ont été confirmés par culture. Parmi ces patients, 46 (39,3%) avaient une infection à VIH confirmée. Trente-quatre patients co-infectés (73,9%) avaient une tuberculose extra pulmonaire (cette forme était associée à la co-infection (p=0,04)). Tous les patients ont été mis sous traitement antituberculeux et antirétroviral selon l'indication. L'évolution était favorable chez 32 patients (69,6%) et 10 décès ont été enregistrés (21,7%). La mortalité était plus élevée chez les co-infectés que chez les tuberculeux non atteints par le VIH (8,4%), (p=0,04). Cette étude a objectivé une prévalence relativement élevée de l'infection par le VIH parmi les tuberculeux. La co-infection Tuberculose-VIH est associée aux formes graves de la tuberculose et à une augmentation de la mortalité chez les tuberculeux, d'où l'intérêt du renforcement des activités conjointes de lutte contre cette co-infection.

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Section: Aux Editeurs Du Journal Panafricain De Médecineunclassified

Co-infection VIH chez les tuberculeux suivis au service des maladies infectieuses du CHU Ibn Rochd-Casablanca

Kettani¹,

Jebbar²,

Takourt³

et al. 2018

Pan Afr Med J

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“…Tuberculosis, which is an infectious disease and remains a major public health problem as well as a leading cause of morbidity, has plagued human beings for thousands of years [ 1 , 6 , 23 ]. In recent years, the incidences and mortality of tuberculosis have been rising.…”

Section: Discussionmentioning

confidence: 99%

“…As a common infectious disease, the prevalence of tuberculosis (TB) has been increasing around the globe, especially in Asia and Africa, and is influenced by multiple factors [ 1 – 3 ]. WHO statistics data demonstrate that the world's annual tuberculosis incidence was 8~10 million and approximately 3 million people died of tuberculosis, which is the largest number of deaths caused by a single infectious disease [ 4 – 6 ]. In the past 10 years, the incidence of bacteriologically positive pulmonary tuberculosis patients in our country was less than 30%, as evidenced from the results of the digital epidemiological survey conducted every year [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…China is one of the 22 countries with the highest burden of TB in the world, ranking second in the number of TB patients, after India [ 7 – 10 ]. In addition to environmental factors, an increasing number of studies and reviews indicate that host genetic factors play an important role in susceptibility to tuberculosis [ 6 , 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

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The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γRelease Assay-Positive Patients

Chen

et al. 2017

Disease Markers

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Tuberculosis is caused by mycobacterium, a potentially fatal infectious bacterium. In recent years, TB cases increased in the whole world. WHO statistics data shows that the world's annual tuberculosis incidence was 8~10 million with about 3 million deaths. Several studies have shown that susceptibility to tuberculosis may be associated with IFNGR1 gene polymorphisms. Here, we report the distribution frequency of IFNGR1 gene polymorphisms in 103 cases of IGA-negative patients and 100 cases of IGA-positive patients from China by sequencing the IFNGR1 proximal ~750 bp promoter region. We found a total of 5 types of site mutations: -611 (G/A), -56 (T/C), -255 (C/T), -359 (T/C), and -72 (C/T). The two main types of gene polymorphisms among the IGA-negative and IGA-positive groups were -611 (G/A), with mutation rates of 88.3% and 78.4%, respectively, and -56 (T/C), with mutation rates of 84.5% and 83.8%, respectively, which had no statistical significance, and there was no correlation with the incidence of tuberculosis.

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“…Mycobacterium bovis , the predominant causative agent of bovine tuberculosis (bTB), is a member of the Mycobacterium tuberculosis complex (MTBC), of which other notable members include Mycobacterium tuberculosis and the attenuated M. bovis Bacillus Calmette-Guerin (BCG) vaccine strain. Whilst M. bovis is primarily considered a pathogen of farmed animals including cattle, buffalo, goats and deer 1 , as well as some sylvatic species, other domestic animal species such as pigs, cats, dogs, horses and sheep are considered spill-over hosts. It is also a zoonosis, considered now by the WHO to be a priority disease to tackle 2 .…”

Section: Introductionmentioning

confidence: 99%

Modelling early events in Mycobacterium bovis infection using a co-culture model of the bovine alveolus

Lee

Stewart

Chambers

2020

Sci Rep

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Bovine tuberculosis (bTB), a zoonosis mainly caused by Mycobacterium bovis has severe socio-economic consequences and impact on animal health. Host–pathogen interactions during M. bovis infection are poorly understood, especially early events which are difficult to follow in vivo. This study describes the utilisation of an in vitro co-culture model, comprising immortalised bovine alveolar type II (BATII) epithelial cells and bovine pulmonary arterial endothelial cells (BPAECs). When cultured at air–liquid interface, it was possible to follow the migration of live M. bovis Bacille Calmette-Guérin (BCG) and to observe interactions with each cell type, alongside cytokine release. Infection with BCG was shown to exert a detrimental effect primarily upon epithelial cells, with corresponding increases in IL8, TNFα, IL22 and IL17a cytokine release, quantified by ELISA. BCG infection increased expression of CD54, MHC Class I and II molecules in endothelial but not epithelial cells, which exhibited constitutive expression. The effect of peripheral blood mononuclear cell conditioned medium from vaccinated cattle upon apical-basolateral migration of BCG was examined by quantifying recovered BCG from the apical, membrane and basolateral fractions over time. The numbers of recovered BCG in each fraction were unaffected by the presence of PBMC conditioned medium, with no observable differences between vaccinated and naïve animals.

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La lutte antituberculeuse dans le monde

Cited by 8 publications

References 17 publications

Co-infection VIH chez les tuberculeux suivis au service des maladies infectieuses du CHU Ibn Rochd-Casablanca

Co-infection VIH chez les tuberculeux suivis au service des maladies infectieuses du CHU Ibn Rochd-Casablanca

The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γRelease Assay-Positive Patients

Modelling early events in Mycobacterium bovis infection using a co-culture model of the bovine alveolus

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