La hemoglobina glucosilada como marcador de riesgo de hiperuricemia en la población general

García‐Escobar, Eva; Pérez-Valero, Vidal; Maseda, Diego; Valdés, Sergio; Yahyaoui, Raquel; Hernando, Virginia; Vicioso, María Isabel; Adana, María Soledad Ruiz de; Rodríguez-Espinosa, María de Lourdes; Rojo-Martínez, Gemma; Soriguer, Federico

doi:10.1016/j.medcli.2010.09.044

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…We used multiple linear regression to access the association between HGI, HbA1c, and SUA after adjusting for demographic factors (age), some medical examination parameters (BMI, HGB, TC, LDL-C, TG, BUN, and Hcy), and previous medical history (hypertension, dyslipidemia). Since a previous study indicated that SUA levels are non-linearly correlated with the levels of HbA1c [ 15 ], we used restricted cubic splines [ 25 ] with internal knots at the 25th, 50th, and 75th percentiles of the scale to assess the effect of HGI and HbA1c on SUA when they're treated as continuous variables. Other continuous variables were naturally log-transformed or used by restricted cubic splines for analysis in regression if violating the linearity assumption.…”

Section: Methodsmentioning

confidence: 99%

“…Also, another study of 1636 community‑dwelling persons conducted in Japan suggested SUA levels were inversely correlated HbA1c in men, but positively correlated with HbA1c in women [ 14 ]. Furthermore, there was one study indicating the association between SUA and HbA1c in women was not linear, positive as the HbA1c rose to 7% and then become negative with the further increase of HbA1c [ 15 ]. However, none of the prior studies exploring the association between SUA and HbA1c conducted subgroup analyses by diabetes and sex altogether.…”

Section: Introductionmentioning

confidence: 99%

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Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid

Ying

Wang

et al. 2022

Diabetol Metab Syndr

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Background Hemoglobin glycation index (HGI), which is calculated by blood glucose and hemoglobin A1c(HbA1c), reflects the individual discrepancy in HbA1c. This study aimed to investigate the association between HGI/HbA1c and serum uric acid(SUA) stratified by sex and diabetes. Methods The study recruited 33772 participants who underwent physical examinations between April 2016 and August 2021 in Beijing Chao-Yang Hospital. A random subsample of 3000 subjects was utilized to calculate the formula of HGI and data of the remaining 30772 participants were used for analysis. HGI and HbA1c were categorized according to quartiles (Q1, Q2, Q3, Q4), using Q1 as the reference. We used multiple linear regression and restricted cubic splines for data analysis. Results 30772 participants with a mean age of 44.4 years old were included in the analysis, 48.6% (N = 14944) of which were female and 7.7% (N = 2363) with diabetes. Associations of HGI, HbA1c and SUA were modified by sex and diabetes. The relationship between SUA levels and HGI was positive in women without diabetes, with one unit increase in HGI associating with an 11.3 μmol/L increase in SUA (P < 0.001) after adjusting for other confounders. On average, each one-unit increase in HbA1c was associated with a 14.3 μmol/L decrease in SUA in women with diabetes, a 14.9 μmol/L decrease in SUA in men with diabetes, and a 16.5 μmol/L increase in SUA in women without diabetes (all P < 0.001). The SUA levels in men without diabetes showed a bell-shaped relation with HbA1c, increasing as the HbA1c rose to around 5.7% and then falling with a further increase of HbA1c (P < 0.001). Conclusions SUA levels were inversely correlated with HbA1c in diabetic patients, also in men with prediabetes (HbA1c ≥ 5.7%), but positively correlated with HbA1c and HGI in women without diabetes. Glycemic control may help to reduce the risk of hyperuricemia in non-diabetes women.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%