La gestion des populations : La race ovine INRA 401 : un exemple de souche synthétique

Ricordeau, G.; Tchamitchian, L.; Brunel, J.C.; Nguyen, Thomas; François, D.

doi:10.20870/productions-animales.1992.5.hs.4300

Cited by 9 publications

(7 citation statements)

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“…The experimental animals were Romane lambs, a fixed crossbreed between Romanov x Berrichon du Cher ( Ricordeau et al, 1992 ). Data collected from a total of 1,047 male and female lambs over a period of 5 years were used in this study.…”

Section: Methodsmentioning

confidence: 99%

Genetic Determinism Exists for the Global DNA Methylation Rate in Sheep

et al. 2020

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Recent studies showed that epigenetic marks, including DNA methylation, influence production and adaptive traits in plants and animals. So far, most studies dealing with genetics and epigenetics considered DNA methylation sites independently. However, the genetic basis of the global DNA methylation rate (GDMR) remains unknown. The main objective of the present study was to investigate genetic determinism of GDMR in sheep. The experiment was conducted on 1,047 Romane sheep allocated into 10 half-sib families. After weaning, all the lambs were phenotyped for global GDMR in blood as well as for production and adaptive traits. GDMR was measured by LUminometric Methylation Analysis (LUMA) using a pyrosequencing approach. Association analyses were conducted on some of the lambs (n = 775) genotyped by using the Illumina OvineSNP50 BeadChip. Blood GDMR varied among the animals (average 70.7 ± 6.0%). Female lambs had significantly higher GDMR than male lambs. Inter-individual variability of blood GDMR had an additive genetic component and heritability was moderate (h2 = 0.20 ± 0.05). No significant genetic correlation was found between GDMR and growth or carcass traits, birthcoat, or social behaviors. Association analyses revealed 28 QTLs associated with blood GDMR. Seven genomic regions on chromosomes 1, 5, 11, 17, 24, and 26 were of most interest due to either high significant associations with GDMR or to the relevance of genes located close to the QTLs. QTL effects were moderate. Genomic regions associated with GDMR harbored several genes not yet described as being involved in DNA methylation, but some are already known to play an active role in gene expression. In addition, some candidate genes, CHD1, NCO3A, KDM8, KAT7, and KAT6A have previously been described to be involved in epigenetic modifications. In conclusion, the results of the present study indicate that blood GDMR in domestic sheep is under polygenic influence and provide new insights into DNA methylation genetic determinism.

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Section: Methodsmentioning

confidence: 99%

Genetic Determinism Exists for the Global DNA Methylation Rate in Sheep

et al. 2020

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“…The experimental animals were Romane ewes reared at the INRAE La Fage Experimental Farm ( Causse du Larzac , Saint-Jean Saint-Paul, southern France) between 2005 and 2019 (n=1034) (R icordeau et al . 1992).…”

Section: Methodsmentioning

confidence: 99%

“…The experiments described here fully comply with applicable legislation on research involving animal subjects in accordance with the European Union Council directive and 2019 (n=1034) (RICORDEAU et al 1992). Ewes were reared exclusively outdoors on approximately 280 ha of rangelands, in a flock of 250 reproductive females present each year.…”

Section: Animals and Managementmentioning

confidence: 99%

Genome-wide analyses reveal a strong association between LEPR gene variants and body fat reserves in ewes

Macé

Gonzalez-Garcia

Foulquie

et al. 2021

Preprint

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Among the adaptive capacities of animals, the management of energetic body reserves (BR) through the BR mobilization and accretion processes (BR dynamics, BRD) has become an increasingly valuable attribute for livestock sustainability, allowing animals to cope with more variable environments. BRD has previously been reported to be heritable in ruminants. In the present study, we conducted genome-wide studies (GWAS) in sheep to determine genetic variants associated with BRD. BR levels and BR changes over time were obtained through body condition score measurements at eight physiological stages throughout each productive cycle in Romane ewes (n=1034) and were used as phenotypes for GWAS. After quality controls and imputation, 48,513 single nucleotide polymorphisms (SNP) were included in the GWAS. Among the QTLs identified, a major QTL associated with BR levels during pregnancy and lactation was identified on chromosome 1. In this region, several significant SNPs mapped to the leptin receptor gene (LEPR), among which one SNP mapped to the coding sequence. The point mutation induces the p.P1019S substitution in the cytoplasmic domain, close to tyrosine phosphorylation sites. The frequency of the SNP associated with increased BR levels was 32%, and the LEPR genotype explained up to 5% of the variance of the trait. These results provide strong evidence for involvement of LEPR in the regulation of BRD in sheep and highlight it as a major candidate for improving adaptive capacities.

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“…Ewes originated from 77 sires. The Romane breed is a composite breed developed by INRA by crossing Romanov, prolific hardy sheep, with Berrichon du Cher known for its meat production qualities (Ricordeau, Tchamitchian, Brunel, Nguyen, & François, 1992). This breed is used for meat sheep production throughout France and is the third meat sheep breed for which a national breeding scheme has been developed.…”

Section: Ethical Compliances and Animalsmentioning

confidence: 99%

Genetic parameters estimates for ewes’ behavioural reactivity towards their litter after lambing

Hazard

Macé

Kempeneers

et al. 2020

J Animal Breeding Genetics

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In livestock, improving maternal reactivity towards the litter is an important issue in breeding strategies to promote production and animal welfare. As of yet, no studies have investigated the within‐breed genetic variation of maternal reactivity in sheep. The objective of this study was to estimate the genetic parameters of maternal reactivity traits. A total of 1,095 primiparous and 1,441 multiparous Romane ewes were phenotyped 24 hr postlambing using a behavioural test (arena test, AT) over a 10‐year experimental period. The test consisted of three successive phases evaluating the ewe's attraction to her litter, reactivity to separation from her litter, and reactivity to a conflict between attraction to her litter and avoidance of a motionless human. The ewes were reared exclusively on rangelands (South of France) and lambed outdoors in the spring. High‐pitched bleating and low‐pitched bleating in the AT were mostly highly heritable (0.39‒0.46). Heritabilities were moderate for proximity to the litter in the presence of a human (0.27) and low for locomotion and vigilance in the AT (0.09‒0.15). The measurements of a given behaviour in the three phases of the AT were highly genetically correlated. Few genetic correlations were found between the different behavioural traits in the AT, the highest correlations being between high‐pitched bleating and low‐pitched bleating (−0.43 to −0.77). In conclusion, our findings demonstrate moderate‐to‐high heritability for maternal reactivity traits. These traits could be included in genetic selection schemes to enhance maternal attachment provided there is no unfavourable link with other production traits.

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La gestion des populations : La race ovine INRA 401 : un exemple de souche synthétique

Cited by 9 publications

References 0 publications

Genetic Determinism Exists for the Global DNA Methylation Rate in Sheep

Genetic Determinism Exists for the Global DNA Methylation Rate in Sheep

Genome-wide analyses reveal a strong association between LEPR gene variants and body fat reserves in ewes

Genetic parameters estimates for ewes’ behavioural reactivity towards their litter after lambing

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