La fibrose pulmonaire idiopathique

Hennion, Nathan; Desseyn, Jean‐Luc; Gottrand, Frédéric; Wémeau-Stervinou, Lidwine; Gouyer, Valérie

doi:10.1051/medsci/2022084

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…IPF is a progressive and irreversible lung disease with different etiology. There is no effective treatment but lung transplantation for IPF patients ( 22 ). A new mechanism, copper-dependent cell death, has been reported to be strongly associated with disease progression through the aggregation of lipoylated mitochondrial enzymes and loss of iron-suffer cluster proteins ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

Identification and immunological characterization of cuproptosis-related molecular clusters in idiopathic pulmonary fibrosis disease

et al. 2023

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BackgroundIdiopathic pulmonary fibrosis (IPF) has attracted considerable attention worldwide and is challenging to diagnose. Cuproptosis is a new form of cell death that seems to be associated with various diseases. However, whether cuproptosis-related genes (CRGs) play a role in regulating IPF disease is unknown. This study aims to analyze the effect of CRGs on the progression of IPF and identify possible biomarkers.MethodsBased on the GSE38958 dataset, we systematically evaluated the differentially expressed CRGs and immune characteristics of IPF disease. We then explored the cuproptosis-related molecular clusters, the related immune cell infiltration, and the biological characteristics analysis. Subsequently, a weighted gene co-expression network analysis (WGCNA) was performed to identify cluster-specific differentially expressed genes. Lastly, the eXtreme Gradient Boosting (XGB) machine-learning model was chosen for the analysis of prediction and external datasets validated the predictive efficiency.ResultsNine differentially expressed CRGs were identified between healthy and IPF patients. IPF patients showed higher monocytes and monophages M0 infiltration and lower naive B cells and memory resting T CD4 cells infiltration than healthy individuals. A positive relationship was found between activated dendritic cells and CRGs of LIPT1, LIAS, GLS, and DBT. We also identified cuproptosis subtypes in IPF patients. Go and KEGG pathways analysis demonstrated that cluster-specific differentially expressed genes in Cluster 2 were closely related to monocyte aggregation, ubiquitin ligase complex, and ubiquitin-mediated proteolysis, among others. We also constructed an XGB machine model to diagnose IPF, presenting the best performance with a relatively lower residual and higher area under the curve (AUC= 0.700) and validated by external validation datasets (GSE33566, AUC = 0.700). The analysis of the nomogram model demonstrated that XKR6, MLLT3, CD40LG, and HK3 might be used to diagnose IPF disease. Further analysis revealed that CD40LG was significantly associated with IPF.ConclusionOur study systematically illustrated the complicated relationship between cuproptosis and IPF disease, and constructed an effective model for the diagnosis of IPF disease patients.

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Section: Discussionmentioning

confidence: 99%

Identification and immunological characterization of cuproptosis-related molecular clusters in idiopathic pulmonary fibrosis disease

et al. 2023

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Insights on the Tunisian Prickly Pear Molasses as a Potential Antifibrotic and Antioxidant Candidate Against Lung Fibrosis

Bahri,

Bouazizi,

Nahdi

et al. 2024

Chemistry & Biodiversity

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Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial disease leading to pulmonary damage and respiratory failure. We aimed to investigate the effect of prickly pear molasses (PPM) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM) in Wistar rat. Animals were divided into 5 groups: the control group (G1), the BLM group (G2) and three groups (G3, G4, G5) receiving a single intra‐tracheal injection of BLM (4 mg/kg) and PPM (at 2, 4.5 and10 %) that was introduced into the diet one week before BLM injection and continued for 3 weeks. Our phytochemical results revealed significant polyphenol and flavonoid content. LCMS analysis revealed the presence of Sinapinic acid, t‐ferulic acid, t‐cinnamic acid, Caffeic acid, gallic acid and vallinic acid among others. Our histological study revealed significant decrease in collagen deposition in the groups of rats treated with 4.5% and 10% molasses compared to BLM group. Oxidative stress in pulmonary tissues was investigated using catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) assays. Treatment with PPM normalized the disturbance in the level of these oxidative markers in G3,G4, G5 compared to G2. In conclusion, PPM exhibit antifibrotic and antioxidant activities in BLM model of lung fibrosis.

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Développement et caractérisation d’un modèle de fibrose pulmonaire idiopathique et recherche de nouvelles cibles thérapeutiques

Hennion,

Humez,

Gottrand

et al. 2024

Revue des Maladies Respiratoires

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La fibrose pulmonaire idiopathique

Cited by 4 publications

References 33 publications

Identification and immunological characterization of cuproptosis-related molecular clusters in idiopathic pulmonary fibrosis disease

Identification and immunological characterization of cuproptosis-related molecular clusters in idiopathic pulmonary fibrosis disease

Insights on the Tunisian Prickly Pear Molasses as a Potential Antifibrotic and Antioxidant Candidate Against Lung Fibrosis

Développement et caractérisation d’un modèle de fibrose pulmonaire idiopathique et recherche de nouvelles cibles thérapeutiques

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