La diphtérie cutanée

Mofredj, A.; Guerin, J.-M.; Falfoul-Borsali, N; Level, C

doi:10.1016/s0248-8663(05)81481-x

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…Coinfection could contribute to an increase of severity, compared to the same infection without C. diphtheriae . The classic clinical presentation is an ulcer covered with a pseudomembrane ( 26 , 27 ). The pathogenicity of C. diphtheriae strains in this kind of context is not proved and the treatment should cover other pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia

et al. 2023

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“…Co-infection could contribute to an increase of severity, compared to the same infection without C. diphtheriae. The classic clinical presentation is an ulcer covered with a pseudomembrane (32,33). The pathogenicity of C. diphtheriae strains in this kind of context is not proved and the treatment should cover other pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Genomic epidemiology ofCorynebacterium diphtheriaein New Caledonia

Tessier

Hennart

Badell-Ocando

et al. 2022

Preprint

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Objectives: An increasing number of isolations of Corynebacterium diphtheriae has been observed in recent years in the archipelago of New Caledonia. We aimed to analyze the clinical and microbiological features of samples with C. diphtheriae. Methods: All C. diphtheriae isolates identified in New Caledonia from May 2015 to May 2019 were included. For each case, a retrospective consultation of the patient files was conducted. Antimicrobial susceptibility phenotypes, tox gene and diphtheria toxin expression, biovar and the genomic sequence were determined. Core genome multilocus sequence typing (cgMLST), 7-gene MLST and search of genes of interest were performed from genomic assemblies. Results: 58 isolates were included, with a median age of patients of 28 years (range: 9 days to 78 years). Cutaneous origin accounted for 51 of 58 (87.9%) isolates, and C. diphtheriae was associated with Staphylococcus aureus and/or Streptococcus pyogenes in three quarters of cases. Half of cases came either from the main city Noumea (24%, 14/58) or from the sparsely populated island of Lifou (26%, 15/58). Six tox-positive isolates were identified, associated with recent travel to Vanuatu; 5 of these cases were linked and cgMLST confirmed recent transmission. Two cases of endocarditis in young female patients with a history of rheumatic fever involved tox-negative isolates. The 58 isolates were mostly susceptible to commonly used antibiotics. In particular, no isolate was resistant to the first-line molecules amoxicillin or erythromycin. Resistance to tetracycline was found in a genomic cluster of 17 (29%) isolates, 16 of which carried the tetO gene. There were 13 cgMLST sublineages, most of which were also observed in the neighboring country Australia. Conclusions: Cutaneous infections may harbor non-toxigenic C. diphtheriae isolates, which circulate largely silently in non-specific wounds. The possible introduction of tox-positive strains from a neighboring island illustrates that diphtheria surveillance should be maintained in New Caledonia, and that immunization in neighboring islands must be improved. Genomic sequencing uncovers how genotypes circulate locally and across neighboring countries.

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La diphtérie dans l'actualité

Lafaix

1994

La Revue de Médecine Interne

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La diphtérie cutanée

Cited by 6 publications

References 45 publications

Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia

Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia

Genomic epidemiology ofCorynebacterium diphtheriaein New Caledonia

La diphtérie dans l'actualité

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