La chirurgie de la cataracte à petite incision manuelle : experience d’un service régional de soins oculaires au Togo

Saa, Kassoula Batomaguela Nonon

doi:10.1016/j.jfo.2017.09.009

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…Moreover, these second-generation CARs, which target CD19 antigen (CD19-specific scFv), are highly active against B cell malignancies and have promising clinical benefit (31,32). In order to overcome the limitations of each individual costimulatory domain, the third generation CARs were proposed to simultaneously combine two costimulatory signaling (CD28 and 4-1BB), which presents a superior expansion and longer persistence than secondgeneration (33).…”

Section: Comparison Of Car and Tcr Therapiesmentioning

confidence: 99%

Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons

et al. 2021

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This review provides insight into the role of engineered T-cell receptors (TCRs) in immunotherapy. Novel approaches have been developed to boost anticancer immune system, including targeting new antigens, manufacturing new engineered or modified TCRs, and creating a safety switch for endo-suicide genes. In order to re-activate T cells against tumors, immune-mobilizing monoclonal TCRs against cancer (ImmTAC) have been developed as a novel class of manufactured molecules which are bispecific and recognize both cancer and T cells. The TCRs target special antigens such as NY-ESO-1, AHNAKS2580F or ERBB2H473Y to boost the efficacy of anticancer immunotherapy. The safety of genetically modified T cells is very important. Therefore, this review discusses pros and cons of different approaches, such as ImmTAC, Herpes simplex virus thymidine kinase (HSV-TK), and inducible caspase-9 in cancer immunotherapy. Clinical trials related to TCR-T cell therapy and monoclonal antibodies designed for overcoming immunosuppression, and recent advances made in understanding how TCRs are additionally examined. New approaches that can better detect antigens and drive an effective T cell response are discussed as well.

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Section: Comparison Of Car and Tcr Therapiesmentioning

confidence: 99%