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Abstract

Background: Traditionally Gloriosa superba is being used as a medicinal plant in outskirts of belagavi, we evaluated and compared the analgesic and anti-inflammatory activities of hydroalcoholic extract of dried aerial parts (rhizomes) of G. superba with standard drugs. Methods: This experimental animal study was carried out in the Research Laboratory, Department of Pharmacology, BIMS, Belagavi. Prior permission from institutional ethical committee and institutional animal ethics committee was taken. Albino rats and Albino mice were used. Acute toxicity study was also done according to OECD guideline no. 425 and test doses were decided accordingly. The experimental models of Eddy's hot plate method was used to study the analgesic activity whereas formalin induced peritonitis and cotton pellet granuloma models were used for anti-inflammatory action. Statistical analysis was performed using Mann-whitney U test and chi-square test (SPSS software version 22). Results: In eddy's hot plate method, for G. superba extract of 400mg/kg, percentage increase in reaction time of at 120 mins was 60.49%, in formalin induces peritonitis method, for G. superba extract of 400mg/kg, percentage inhibition of peritoneal exudate was 47.14%. In cotton pellet induced granuloma method, for G. superba extract of 400mg/kg, percentage inhibition of granuloma formation was 50.32%. All the results of 4 different groups in each method showed significant difference in their respective pharmacological activities (Chi Square values: 14.4, 14.4, 75.2). Conclusion: Hydroalcoholic extract of G. superba has shown significant analgesic and anti-inflammatory activity in our study. INTRODUCTION:Pain is an unpleasant sensation and emotional experience associated with actual or potential tissue damage or described in terms of such damage 1 . The pathophysiology of pain involves 2 components, peripheral nociception and central mechanism.