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Abstract

Introduction: Actuality is due to rather understudied state of fibrinolytic reactions in case of NN with acute IAI which is to be found in practice more frequent. Objective of the study was studying of the features of fibrinolytic activity in case of IAI, that is being developed underlying NN.Materials and Methods: 100 albino non-pedigree rats. IAI was simulated through the intra-abdominal puncture injection of a 20% auto fecal mixture. NN was simulated by subcutaneous introduction of 5% sodium nitrite solution on distilled water. In the course of the study total TFA, NFA and EFA of blood plasma were studied. The animals were divided into such groups: 1 -intact animals with IAI models, 2 -animals with models of IAI underlying NN. Results:The activity of fibrinolysis in animals with NN models predominated over the one in intact animals. In 6 hours since IAI was modeled, FA started increasing in both animal groups. However, all of TFA, EFA and NFA in group 1 were increasing statistically significantly. Whereas group 2 was affected by a minor increase. In 12 hours in group 1 FA of plasma was increasing statistically significantly. In group 2 FA of plasma was increasing insignificantly. There was a meaningful increase of EFA in group 1, in contrast, it was insignificant in group 2. The ratio between EFA and NFA decreased in group 1. In contrast, this ratio in group 2 increased statistically significantly and the parameters of EFA indicator in group 2 were statistically significantly higher. In 24 hours, parameters of TFA, NFA and EFA indica-tors in both groups have not changed much. At the same time, the ratio between EFA and NFA was increasing statistically significantly in group 1. In group 2 the ratio decreased. In 48 hours, FA plasma and the ratio of different fibrinolysis elements did not change much in group 1. The parameters of TFA and EFA in group 2 were increasing statistically significantly. The parameters of NFA were decreasing statistically significantly. The ratio between EFA and NFA in group 2 was decreasing very significantly. Conclusiona) The increase in the fibrinolytic activity of blood plasma with the non-enzymatic mechanism's predomination have been found in experimental nephrosis-nephritis case.b) The activation of fibrinolysis with balance maintenance between its links within 24 hours has been observed in experimental acute intra-abdominal infection case. c) In 6 hours, the development of acute intra-abdominal infection in animals with simulated nephrosis-nephritis differs substantially in its quantitative characteristics of the fibrinolytic activity of plasma blood, which is shown by its lack of proper increase, development of imbalance be-tween the links of fibrinolysis, uncontrolled increase of the activity of fermentation mechanisms with disseminated intravascular coagulation syndrome in 48 hours.d) The basis of the differences that have been detected are the changes in the functional activity of the fibrinolytic system caused by nephrosis-nephritis influence that, in addition to changes in ...