Abstract:BackgroundMitochondrial dysfunction play a significant role in the patomechanism of several neurodegenerative disorders, including Huntington’s disease. PGC-1α is a master regulator of mitochondrial biogenesis, thus it could serve as a potential therapeutic target in these disorders. Due to the several tissue-specific isoforms and the limitation of the blood-brain barrier penetration, the brain specific stimulation of the expression of this transcriptional factor is difficult. MethodsWe have used several diffe… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.