L1, β‐catenin, and E‐cadherin expression in patients with colorectal cancer: Correlation with clinicopathologic features and its prognostic significance

Fang, Qingxia; Lü, Liang-Zhong; Yang, Bo; Zhao, Zhenze; Wu, Yue; Xing, Zheng

doi:10.1002/jso.21537

Cited by 21 publications

(11 citation statements)

References 25 publications

(27 reference statements)

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“…[14,15,18–21,25–47] In addition, 9 studies showed a relationship between cytoplasmic β-catenin expression and pathological features or OS [17,19–21,25,33,34,37,43] (Table 2). Thirteen studies were selected for analysis of the prognostic value of reduced β-catenin expression in the membrane of CRC [17,19–21,26,31,34,35,38,43,48–50] (Table 3). There were also 3 studies included to examine the predictive role of nuclear β-catenin expression in the invasive front of tumor [17,41,51] (Table 4).…”

Section: Resultsmentioning

confidence: 99%

Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma

et al. 2016

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“…32,33 Previous prognostic data on CTNNB1 alterations in colorectal cancer are inconclusive. 34-52 Two large studies 42,43 (N>540) demonstrated no prognostic role of CTNNB1 alterations. However, none of the previous studies 34-52 has examined interactive associations of tumor CTNNB1 and patient’s BMI or physical activity.…”

Section: Discussionmentioning

confidence: 99%

Association of CTNNB1 (β-Catenin) Alterations, Body Mass Index, and Physical Activity With Survival in Patients With Colorectal Cancer

Morikawa

Kuchiba²,

Yamauchi³

et al. 2011

JAMA

163

193

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Context Alterations of WNT-CTNNB1 (β-catenin) signaling play roles in colorectal carcinogenesis and metabolic diseases. Objective To test the hypothesis that CTNNB1 activation in colorectal cancer might modify prognostic associations of body mass index (BMI) and post-diagnosis physical activity. Design We utilized molecular pathological epidemiology (MPE, or molecular pathologic epidemiology) design, investigating interactive effects of tumor and lifestyle factors on tumor behavior. We evaluated CTNNB1 (HGNC ID: 2514) localization by immunohistochemistry in 955 colon and rectal cancers. Cox proportional hazards model was used to compute mortality hazard ratio (HR), adjusting for covariates, including microsatellite instability (MSI), CpG island methylator phenotype (CIMP), LINE-1 methylation, KRAS, BRAF, PIK3CA, and TP53 (p53). Setting Two U.S. nationwide prospective cohort studies, the Nurses’ Health Study and the Health Professional Follow-up Study. Results In obese patients (BMI ≥30 kg/m2), nuclear CTNNB1 positivity was associated with significantly better cancer-specific survival [adjusted HR=0.24; 95% confidence interval (CI), 0.12-0.49; 5-year survival, 0.85 vs. 0.78 for nuclear CTNNB1-positive vs. negative patients] and overall survival (adjusted HR=0.56; 95% CI, 0.35-0.90; 5-year survival, 0.77 vs. 0.74 for nuclear CTNNB1-positive vs. negative patients), while CTNNB1 status was not associated with prognosis among nonobese patients (Pinteraction=0.0003 and 0.034 for cancer-specific and overall survival, respectively). Among nuclear CTNNB1-negative stage I-III patients, post-diagnosis physical activity was associated with better cancer-specific survival [adjusted HR=0.33; 95% CI, 0.13-0.81; ≥18 vs. <18 MET (metabolic equivalent task) hours/week; 5-year survival, 0.97 vs. 0.89] while physical activity was not associated with survival among nuclear CTNNB1-positive stage I-III patients (Pinteraction=0.046). Conclusions This MPE study showed that CTNNB1 activation was associated with better cancer-specific and overall survival only among obese patients. Post-diagnosis physical activity was associated with better cancer-specific survival only among nuclear CTNNB1-negative patients. Our novel MPE data support a role of interactions between tumor and host factors influencing tumor aggressiveness.

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“…Thirty studies [5–8, 12, 14, 15, 17–25, 27, 28, 30–37, 39–41, 43] with data from 7743 patients were available to evaluate the effect of L1CAM expression on OS. The random-effects model was applied to calculate the pooled HR and 95%CI because of the significant heterogeneity among studies (I 2 =81.8%, P<0.01).…”

Section: Resultsmentioning

confidence: 99%

Prognostic significance of L1 cell adhesion molecule in cancer patients: A systematic review and meta-analysis

et al. 2016

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The L1 cell adhesion molecule (L1CAM) extensively participates in nervous system development and the malignant progression of human tumours. The prognostic value of L1CAM for the survival of patients with solid tumours remains controversial. The present meta-analysis was thus performed to highlight the relationship between L1CAM expression and prognosis in cancer patients. Relevant publications were identified after searching several widely used databases, including PubMed, EMBASE and the ISI Web of Science. A fixed-effect or random-effect meta-analytical model was employed to correlate L1CAM expression with different outcome measures in both entire tumours and stratified subgroups. 37 studies in total with 8552 patients were eligible for the final analysis. Combined hazard ratios (HRs) and 95% confidence intervals (CIs) suggested that high L1CAM expression had an unfavourable impact on overall survival (HR=2.06, 95%CI 1.65-2.57, P<0.001), disease-specific survival (HR=2.45, 95%CI 1.48-4.05, P<0.001), disease-free survival (HR=2.42, 95%CI 1.4-4.19, P=0.002) and progression-free survival/recurrence-free survival (HR=2.07, 95%CI 1.41-3.05, P<0.001). Subgroup analysis revealed a similar correlation in most tumour types. Overall, L1CAM might be an effective poor prognostic factor for patients with various tumour types.

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L1, β‐catenin, and E‐cadherin expression in patients with colorectal cancer: Correlation with clinicopathologic features and its prognostic significance

Abstract: Our study provided reference for identifying patients who need adjuvant chemotherapy. L1, β-catenin, and E-cadherin could be considered as biomarkers to predict whether CRC patients will or will not respond to adjuvant chemotherapy.

Cited by 21 publications

References 25 publications

Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma

Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma

Association of CTNNB1 (β-Catenin) Alterations, Body Mass Index, and Physical Activity With Survival in Patients With Colorectal Cancer

Prognostic significance of L1 cell adhesion molecule in cancer patients: A systematic review and meta-analysis

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