Abstract:L1 retrotransposition is a significant source of endogenous mutagenesis in the human genome. This process is driven by a handful of highly active source L1s in each individual. L1 mobilization can occur in natural pluripotent cells, such as the stem cells present in the early embryo, and during the artificial generation of human induced pluripotent stem cells (hiPSCs) via cellular reprogramming. hiPSCs have been proposed for use in regenerative medicine, rendering an understanding of L1 retrotransposition and … Show more
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