L'ultrastructure du foie humain lors d'ict�res idiopathiques chroniques

Electron Microscopy of the Liver in non Hemolytic Acholuric Jaundice with Kernicterus (Crigler-Najjar) and in Idiopathic Conjugated Hyperbilirubinemia (Rotor)

“…They were characterized by irregular size and shape of these organelles plus the so-called " fibrillary degeneration" . These morphological findings have been previously described by M inio et al [7,8] and Barone [2] both in Rotor and Dubin-Johnson cases. There is also agreement between our findings and theirs in what is related to the sinusoidal pole pathology of the hepatic cell.…”

“…There is also agreement between our findings and theirs in what is related to the sinusoidal pole pathology of the hepatic cell. However, we have not found the pigment described by M inio [8] and Cede (cit. Minio) in their R otor cases.…”

“…Few cases of idiopathic conjugated hyperbilirubinemia (Rotor) have been studied with the aid of the electron microscope [8].…”

History of Electron Microscopy in Switzerland

“…Indeed liver has been one of the interests of the EM Center in Lausanne, and fellows such as F. Minio The electron microscopy in Lausanne is in some ways synonimous with D.Gardiol and liver. Since 1965, Gardiol has contributed to all important ultrastructural investigations on liver morphology and pathology (56,57).…”

“…and others have contributed to these studies(54)(55)(56)(57). In the sixties and seventies, kidney has been investigated by O.Bucher and E.Reale(58,59); the skin, especially pigmented cells of the epidermis by E.Frenk(60)(61)(62) and M.Stoian(63).…”