l-Tryptophan and neuroendocrine regulation in neurologic patients: Hormone responses to l-tryptophan loading in patients with hypothalamic lesions☆

Hyyppä, Markku T.; Jolma, Tapani; Långvik, Vivi-Ann; Kytömäki, O.; Syvälahti, Erkka

doi:10.1016/0306-4530(77)90004-x

Cited by 10 publications

(1 citation statement)

References 24 publications

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“…Oral Trp administration boosted serotonin but decreased plasma cortisol levels in patients with neurological diseases. Acute MS and other neurologic symptoms were alleviated 138,139 . Dietary Trp can be metabolized by gut microbes or host cells after enteric absorption.…”

Section: Significant Associations Between Microbial Metabolites and Ms In Humansmentioning

confidence: 99%

Regulation of common neurological disorders by gut microbial metabolites

Park

Kim

2021

Exp Mol Med

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The gut is connected to the CNS by immunological mediators, lymphocytes, neurotransmitters, microbes and microbial metabolites. A mounting body of evidence indicates that the microbiome exerts significant effects on immune cells and CNS cells. These effects frequently result in the suppression or exacerbation of inflammatory responses, the latter of which can lead to severe tissue damage, altered synapse formation and disrupted maintenance of the CNS. Herein, we review recent progress in research on the microbial regulation of CNS diseases with a focus on major gut microbial metabolites, such as short-chain fatty acids, tryptophan metabolites, and secondary bile acids. Pathological changes in the CNS are associated with dysbiosis and altered levels of microbial metabolites, which can further exacerbate various neurological disorders. The cellular and molecular mechanisms by which these gut microbial metabolites regulate inflammatory diseases in the CNS are discussed. We highlight the similarities and differences in the impact on four major CNS diseases, i.e., multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, and autism spectrum disorder, to identify common cellular and molecular networks governing the regulation of cellular constituents and pathogenesis in the CNS by microbial metabolites.

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Section: Significant Associations Between Microbial Metabolites and Ms In Humansmentioning

confidence: 99%

Regulation of common neurological disorders by gut microbial metabolites

Park

Kim

2021

Exp Mol Med

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The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects

et al. 1982

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In order to assess the effects of increased central nervous system serotonergic function in humans on prolactin (PRL), growth hormone (GH) and mood, intravenous L-tryptophan (TRP) was administered to ten healthy subjects. The TRP infusion induced robust increases in PRL in all ten subjects. A significant increase in GH concentration was also observed, although the response was more variable. The subjects reported feeling significantly more high, mellow, and drowsy following the TRP infusion in comparison to placebo. These findings indicate an important role for serotonin in PRL and GH secretion, as well as in mood regulation. The intravenous TRP challenge may be of use in the study of serotonergic function in a variety of neurologic and psychiatric diseases.

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The effect of IV l-tryptophan on prolactin, growth hormone, and mood in healthy subjects

et al. 1982

View full text Add to dashboard Cite

In order to assess the effects of increased CNS serotonergic function in humans on prolactin (PRL), growth hormone (GH), and mood, IV L-tryptophan (TRP) was administered to ten healthy subjects. The TRP infusion induced robust increases in PRL in all ten subjects. A significant increase in GH concentration was also observed, although the response was more variable. The subjects reported feeling significantly more 'high', 'mellow', and 'drowsy' following the TRP infusion in comparison to placebo. These findings indicate an important role for serotonin in PRL and GH secretion, as well as in mood regulation. The IV TRP challenge may be of use in the study of serotonergic function in a variety of neurologic and psychiatric diseases.

show abstract

l-Tryptophan and neuroendocrine regulation in neurologic patients: Hormone responses to l-tryptophan loading in patients with hypothalamic lesions☆

Cited by 10 publications

References 24 publications

Regulation of common neurological disorders by gut microbial metabolites

Regulation of common neurological disorders by gut microbial metabolites

The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects

The effect of IV l-tryptophan on prolactin, growth hormone, and mood in healthy subjects

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