L-shell x-ray fluorescence computed tomography (XFCT) imaging of Cisplatin

Bazalova, M.; Ahmad, Moiz; Pratx, Guillem; Li, Xing

doi:10.1088/0031-9155/59/1/219

Cited by 30 publications

(30 citation statements)

References 27 publications

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“…Recent XFCT work by several groups (Pratx et al 2010, Cong et al 2011, Kuang et al 2013, Kuang et al 2014, Bazalova et al 2014, Ren et al 2014, Feng et al 2014, Ahmad, Bazalova, Xiang and Xing 2014, Ahmad, Pratx, Bazalova and Xing 2014, Sjölin and Danielsson 2014, Bazalova-Carter et al 2015, Ahmad et al 2015) have shown that XFCT can have theoretical molecular sensitivities down to 10 pM for 10 nm diameter AuNPs (Ahmad, Bazalova, Xiang and Xing 2014). Gold concentrations down to 2.5 mg/ml were experimentally detectable with a clinical x-ray source at 14 mGy in a proof of concept setup (Ahmad et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Feasibility study of Compton cameras for x-ray fluorescence computed tomography with humans

et al. 2016

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X-ray fluorescence imaging is a promising imaging technique able to depict the spatial distributions of low amounts of molecular agents in vivo. Currently, the translation of the technique to preclinical and clinical applications is hindered by long scanning times as objects are scanned with flux-limited narrow pencil beams. The study presents a novel imaging approach combining x-ray fluorescence imaging with Compton imaging. Compton cameras leverage the imaging performance of XFCT and abolish the need of pencil beam excitation. The study examines the potential of this new imaging approach on the base of Monte-Carlo simulations. In the work, it is first presented that the particular option of slice/fan-beam x-ray excitation has advantages in image reconstruction in regard of processing time and image quality compared to traditional volumetric Compton imaging. In a second experiment, the feasibility of the approach for clinical applications with tracer agents made from gold nano-particles is examined in a simulated lung scan scenario. The high energy of characteristic x-ray photons from gold is advantageous for deep tissue penetration and has lower angular blurring in the Compton camera. It is found that Doppler broadening in the first detector stage of the Compton camera adds the largest contribution on the angular blurring; physically limiting the spatial resolution. Following the analysis of the results from the spatial resolution test, resolutions in the order of one centimeter are achievable with the approach in the center of the lung. The concept of Compton imaging allows to distinguish to some extend between scattered photons and x-ray fluorescent photons based on their difference in emission position. The results predict that molecular sensitivities down to 240 pM/l for 5 mm diameter lesions at 15 mGy for 50 nm diameter gold nano-particles are achievable. A 45-fold speed up time for data acquisition compared to traditional pencil beam XFCT could be achieved for lung imaging on cost of a small sensitivity decrease.

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Section: Introductionmentioning

confidence: 99%

Feasibility study of Compton cameras for x-ray fluorescence computed tomography with humans

et al. 2016

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“…4 Additionally, Manohar et al 5 were able to quantify AuNP concentrations down to 20 mgAu ml 21 in planar images of a 1.2-cm diameter phantom using a bench-top L-shell X-ray fluorescence imaging system. The feasibility of L-shell XFCT has therefore been demonstrated both in silica and experimentally, however, a number of challenges prevent us from introducing L-shell molecular imaging into even the pre-clinical settings.…”

Section: Advantages Of L-shell Xfct Compared With K-shell Xfct Imagingmentioning

confidence: 99%

“…4,5 The size of the pencil beam and the transversal scanning parameters define the spatial resolution of XFCT images. Small beam size and fine scanning steps result in high spatial resolution down to 150 mm, with the expense of long imaging times.…”

Section: Imaging Timementioning

confidence: 99%

“…Imaging times can be decreased by using an array of detectors as demonstrated in the simulation work by Bazalova et al 4 Alternatively, a fan or cone beam in conjunction with a collimated detector array, similar to SPECT imaging, could be used to speed up the data acquisition process. Such a set-up has been studied for K-shell XFCT imaging, in which Monte Carlo simulations demonstrated that accurate AuNP concentrations down to 1 mgAu ml 21 could be imaged with a cone beam geometry and two banks of parallel pinhole collimators and a dose of 30 cGy.…”

Section: Imaging Timementioning

confidence: 99%

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The potential of L-shell X-ray fluorescence CT (XFCT) for molecular imaging

Bazalova‐Carter¹

2015

BJR

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X-ray fluorescence CT (XFCT), a novel modality proposed for high-sensitivity high-resolution molecular imaging of probes labelled with a high atomic-number element, has been performed with high-energy K-shell X-rays. XFCT performed with low-energy L-shell X-rays could, in principle, result in an increase of XFCT imaging sensitivity; however, the significant L-shell X-ray attenuation limits its use for imaging of small objects. This commentary discusses the advantages and drawbacks of L-shell XFCT imaging.

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“…[15][16][17][18][19][20] The pencil beam/single collimated beam from polychromatic x-ray tubes [21][22][23][24][25][26][27] is then used to improve the feasibility of using XFCT; however, this technique requires a long scanning time, e.g., 279 min 28 and 180 h. 29 One important reason for the low efficiency is that using a pencil beam setup requires the beam source to be shifted point by point while measuring a single slice of projection data. Similar processes of shifting on detectors are also required for a fan-beam setup with a single pixel detector.…”

mentioning

confidence: 99%

Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging

Zhang

et al. 2017

Opt. Eng

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, "Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging," Opt. Eng. 56(4), 043106 (2017), doi: 10.1117/1.OE.56.4.043106. Abstract. X-ray fluorescence computed tomography (XFCT) was performed on a high-intensity synchrotron radiation source or a pencil beam with a long exposure time due to the low emission and detection efficiency of x-ray fluorescence photons. For the first time, the feasibility and experimental results of a full-field fan-beam XFCT with a photon-counting detector array are presented. This full-field fan-beam XFCT consists of a conventional low-intensity x-ray tube, an energy-sensitive photon-counting detector array, and a tungsten pinhole collimator. A phantom containing gadolinium solution (K α , 42.74 keV) was scanned for 30 min using a polychromatic x-ray fan beam with a third-generation computed tomography (CT) geometry. After scattering and attenuation corrections, experimental results showed that XFCT had better accuracy and performance than spectral CT. Full-field XFCT is a promising modality for biomedical imaging of exogenous molecular probes containing nanoparticles of high atomic number.

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L-shell x-ray fluorescence computed tomography (XFCT) imaging of Cisplatin

Cited by 30 publications

References 27 publications

Feasibility study of Compton cameras for x-ray fluorescence computed tomography with humans

Feasibility study of Compton cameras for x-ray fluorescence computed tomography with humans

The potential of L-shell X-ray fluorescence CT (XFCT) for molecular imaging

Full-field fan-beam x-ray fluorescence computed tomography with a conventional x-ray tube and photon-counting detectors for fast nanoparticle bioimaging

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