l-Proline-catalyzed three-component domino reactions in the regioselective synthesis of novel densely functionalized pyrazolo[3,4-b]pyridines

Abstract

L-Proline-catalyzed three-component domino reactions in the regioselective synthesis of novel densely functionalized pyrazolo [3,4-b] pyridines3

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

“…The regioselectivity of the formation of aromatic pyrazolopyridines 126 was caused by a greater electrophilicity of COCF 3 than COAr-carbonyl group. However, for some combinations of substituents in 5-aminopyrazole 124 and aldehyde 1 dihydropyrazolopyridines 127 without trifluoroacetyl moiety were formed (Figure 10 ; Gunasekaran et al, 2013 ).…”

Three-component one-pot synthesis of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridines

“…Several methods have been devised for the synthesis of substituted pyrazolopyridines [14][15][16][17][18][19][20]. Among them multi-component reactions (MCRs) [21][22][23][24][25] are of increasing importance because of their convergent, atom-economical and productive nature.…”

Selective Synthesis of New Tetracyclic Coumarin‐fused Pyrazolo[3,4‐b]pyridines and Pyrazolo[3,4‐b]pyridin‐6(7H)‐ones

“…The development of new multicomponent reactions has become an active and challenging topic in modern synthetic chemistry because it is a preferred approach to design and discover biologically active compounds . Literature survey a variety of functionalized polycyclic pyrazolo[3,4‐ b ]pyridine derivatives that have been reported . However, several routes have thus far been reported for the construction of coumarin‐fused pyrazolo[3,4‐ b ]pyridines .…”