L-Proline Catalysed Domino Reactions for the Synthesis of Heterocycles

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

“…The efficiency of MCRs can be increased by extensions without adding additional reaction partners, because functional groups are present in the STM that react in Domino-reactions with the newly created functional groups in the MCR as postcondensation modification (PCM) and postcondensation cyclisation (PCC) [88,[114][115][116][117][118][119][120][121][122][123][124]. Scheme 10 shows examples of several Tandem-U-4CR/Diels-Alder, Knoevenagel, Heck or UDC reactions as postcondensation cyclizations (PCCs) [88].…”

“…Functional π-systems [193], norbornene [194] and A3-coupling [117] with MCRs/domino reactions were deployed for DOS. Proline-catalysed domino reactions are used for the synthesis of heterocyclic groups using MCRs [119]. MCR/domino processes develop through rational design and serendipity [116].…”

KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives

“…MCRs provide suitable conditions with high demand in advanced organic synthesis. It is especially accurate in case of heterocycle compounds [16] as those reactions comfort formation of various bonds in one-pot operation [17]. Development of several synthetic methodologies to achieve various diversities of pyrazolopyridines derivatives, exhibits the growing interests into these compounds [18].…”

Ultrasonic-accelerated rapid protocol for the improved synthesis of pyrazoles

“…It is particularly true in case of heterocycles [1] as those reactions facilitate formation of several bonds in one unit operation [2,3]. In the recent years, ultrasound irradiation has gained recognition as a clean and advantageous approach in organic synthesis [4].…”