L-pipecolic acid production in thrA knockout Escherichia coli
Suttilak Khuanwilai
Abstract:L-pipecolic acid (L-PA) is a non-proteinogenic amino acid, however, it is an important precursor and a key ingredient of many pharmaceutically compound syntheses such as immunosuppressants and anesthetics. The production of amino acids via fermentation of microorganisms are getting attention, one of the widely used is an engineered�E. coli. L-PA production in the engineered E. coli uses L-lysine in its cell as a substrate. This research aimed to increase L-PA production by thrA knockout. The thrA encodes homos… Show more
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