L’ocfentanil : un bon exemple des dangers des NPS ( New Psychoactive Substances )

Marchard, Amandine; Martin-Molins, C.; Moal, A.; Vieira, Oscar Vilhena; Sibille, P.; Milan, Nathalie

doi:10.1016/j.toxac.2017.03.091

Cited by 2 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two lethal intoxication cases with ocfentanil have been reported in Belgium [ 15 ] and one in Switzerland [ 12 ]. More ocfentanil related deaths have been also reported in Ireland and France [ 6 , 17 , 18 ]. Ocfentanil is also involved in intoxication cases and deaths in the United States and Canada, where it is also a concern, among other fentanyl analogues [ 67 ].…”

Section: Ocfentanilmentioning

confidence: 99%

“…Ocfentanil was reported in April 2017 as the cause of three nonfatal intoxication cases and two deaths in France [ 17 , 18 ]. The first death concerned a 30-year-old man who was found dead in his apartment next to drug syringes and related paraphernalia.…”

Section: Ocfentanilmentioning

confidence: 99%

“…This concentration could not be evaluated due to the long time interval between the intake of the drug and the blood sampling. Death was not attributed to ocfentanil due to the simultaneous consumption of other drugs [ 18 ]. Ocfentanil was also involved in three nonfatal intoxication cases in France.…”

Section: Ocfentanilmentioning

confidence: 99%

“…In the third case, the blood concentration of ocfentanil was found to be 20.7 μg/L, and acetaminophen was also detected. All victims survived after prompt and proper treatment [ 18 ]. It has to be mentioned here that the concentrations of ocfentanil in nonfatal intoxications were much higher than those reported by Coopman et al [ 13 ] and Dussy et al [ 12 ], who reported fatal cases.…”

Section: Ocfentanilmentioning

confidence: 99%

“…Ocfentanil was the cause of some verified intoxication cases and deaths, mainly in Europe, and threatens to be an imminent hazard to the public safety [ 6 , 11 – 15 ]. Some ocfentanil-related cases have been also presented at different scientific conferences [ 16 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Fentanyls continue to replace heroin in the drug arena: the cases of ocfentanil and carfentanil

et al. 2017

View full text Add to dashboard Cite

PurposeOcfentanil and carfentanil are two potent synthetic opioids that are analogues of fentanyl and are actively involved in the recent fentanyl crisis. The aim of this review is to provide all the available information on these two fentanyl analogues.MethodsAll reviewed information was gathered through a detailed search of PubMed and the World Wide Web using relevant keywords.ResultsLike most of the members of the family of fentanyls, they are either sold as heroin to unsuspecting users or used extensively to lace heroin street samples. Despite the fact that ocfentanil was studied clinically in the early 1990s, it did not manage to find its place in clinical practice. On the other hand, carfentanil is mainly used today as an anesthetic agent in large animals. Ocfentanil and carfentanil are used and abused extensively, mainly in Europe and in the United States. As a result, they are the cause of some verified intoxication cases and deaths worldwide. This review provides information concerning chemistry, synthesis, prevalence, pharmacology, and toxicology, as well as the current legal status of these two fentanyl analogues. Analytical methods developed for the determination of ocfentanil and carfentanil in biological specimens and seized materials, as well as related intoxication and lethal cases are also presented.ConclusionsOcfentanil and carfentanil are undeniably very dangerous opioid drugs and a very serious matter of concern for public safety. The authorities should take the appropriate actions to avoid the expansion of this threat by taking proper and prompt measures.

show abstract