L-NAME prevents anxiety-like and depression-like behaviour in rats
exposed to restraint stress

Sevgi, Serhan; Ozek, M; Eroğlu, L

doi:10.1358/mf.2006.28.2.977840

Cited by 85 publications

(56 citation statements)

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“…The increase in TNF-α levels is implicated in NF-κB activation and iNOS expression in the brain cortex after immobilization stress (6 h), as used in the present study (4). Inhibition of NOS by a nonselective inhibitor like L-NAME (5,35) or by relatively selective inhibitors of nNOS, like 7-nitroindazole (36,37), produced an antianxiety-like effect. Recently, anxiolytic-like activity of aminoguanidine, an inhibitor of the inducible isoform of NOS (7), was reported in mice from our own laboratory.…”

Section: Discussionmentioning

confidence: 90%

Possible Underlying Influence of p38MAPK and NF-κB in the Diminished Anti-anxiety Effect of Diazepam in Stressed Mice

Sharma¹,

Gilhotra²,

Dhingra³

et al. 2011

J Pharmacol Sci

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Abstract. The present study was designed to explore the possible nitriergic influence and role of p38MAPK and NF-κB in the diminished anti-anxiety effect of diazepam in stressed mice, using the elevated plus maze and light/dark box to assess anxiety. Immobilization stress for 6 h enhanced an anxiety-like behavior and increased plasma nitrite levels in mice. Diazepam (2 mg/kg, i.p.) produced an anti-anxiety effect in unstressed mice, but could not produce any change in anxiety levels of stressed mice. SB-203580 (2 mg/kg, i.p.), a specific inhibitor of p38MAPK, per se produced a significant antianxiety-like activity in stressed mice. Administration of a combination of SB-203580 (2 mg/kg, i.p.) and diazepam (2 mg/kg) in stressed mice produced a significantly higher antianxiety-like activity than that produced by SB-203580 alone. Pyrrolidine dithiocarbamate (PDTC), an inhibitor of the activation of NF-κB, per se produced a significant antianxietylike activity in stressed mice. Combination of PDTC and diazepam also served to produce a higher significant antianxiety-like activity in stressed mice than that produced by PDTC alone. Diazepam could not produce any change in plasma nitrite levels in both unstressed and stressed mice. Both SB-203580 (2 mg/kg, i.p.) and PDTC (100 mg/kg, i.p.) significantly decreased plasma nitrite levels in stressed mice. The observations indicate that the diminished anti-anxiety effect of diazepam in stressed mice may involve strong nitriergic influence and may further be p38MAPK-and NF-κB-dependent.

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Section: Discussionmentioning

confidence: 90%

Possible Underlying Influence of p38MAPK and NF-κB in the Diminished Anti-anxiety Effect of Diazepam in Stressed Mice

Sharma¹,

Gilhotra²,

Dhingra³

et al. 2011

J Pharmacol Sci

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show abstract

“…There are several reports that chronic exposure to restraint stress for 15 days (2 hrs daily) leads to the induction of depressive symptoms in rat [32,33]. Chronic injection of corticosterone at an elevated dose has been used in development of stress induced depression model in number of anti depressant studies [34].…”

mentioning

confidence: 99%

Exposure to Hypobaric Hypoxia and Reoxygenation Induces Transient Anxiety-Like Behavior in Rat

Baitharu¹,

Jain²,

Deep³

et al. 2013

JBBS

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Chronic exposure to hypobaric hypoxia (HH) causes memory impairment and prolonged state of mental confusion. However, effect of high altitude exposure on mood state and its underlying mechanisms have been poorly studied. Present study was undertaken to investigate the mood state alteration following chronic exposure to HH. Male Sprague Dawley rats were divided into five groups and exposed to hypoxia for 3, 7, 14 and 21 days in an animal decompression chamber at an altitude of 25,000ft. Anxiety-and depression-like behaviors were assessed by using various mazes along with changes in serotonin and glutamate level. Our study revealed a decrease in exploratory, grooming and rearing behavior in open field test following initial exposure to HH for 7 days without affecting the locomotory behavior. Initial exposure to HH-decreased time spent in open arm of elevated plus maze indicating induction of anxiety-like behavior which normalized on prolonged hypoxic exposure for 21 days. Hypoxic exposure for 7 days induced anhedonia and increased despair behavior in rat while there was steady improvement in these behaviors when exposed for 21 days. Decrease in serotonin level was noted in hippocampus along with elevated corticosterone and glutamate level which gradually decreased on prolonged exposure to HH. These findings suggest that initial exposure to HH increases transient anxiety-like behavior in rats followed by gradual improvement in mood state on prolonged exposure. Further, the study also indicates the involvement of serotonergic system in mood state alteration at high altitude following chronic exposure and reoxygenation.

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“…Generally, tail suspension model are used to evaluate behaviour changes as well as immobilization time. Normally depletion of neurotransmitters like serotonin, nor-adrenaline to leads to depression in body 23 . Depression has been linked to perturbations in the neurotransmission involving brain 5-HT, nor-epinephrine (NE) and dopamine activity 27 -28 (Maes and Meltzer, 1995;Posener et al, 1994).…”

Section: Effect Of Spirulina and Standard Drugon Tail Suspension Testmentioning

confidence: 99%

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2018

IJPSR

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ABSTRACT:The aim of present study on Spirulina platensis (Spirulina) was to evaluate the anti-stress activity. The anti-stress activity was assessed by tail suspension method andcold immobilization induced change of biochemical parameters. Acute toxicity (LD 50 ) of Spirulina platensis values was also studied. Duration of immobilization time and cold immobilization induced alteration of biochemical parameters (liver functioning profiles like-AST, ALT, ALP and liver tissue anti-oxidant profiles like-MDA, SOD, GST) were used as a stress indicator. Spirulina platensis administered orally at two different doses of 200 and 400 mg/kg respectively. Diazepam, a well-known anti-stress drug (2 mg/kg i.p.) was taken as standard drug. The dose of 200 and 400 mg/kg of Spirulina Platensis significantly decreased the duration of immobilization time and also provide protection against stress induced alteration of biochemical parameters. It is concluded that the 200 and 400 mg/kg dose of Spirulina platensis have anti-stress activity.

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L-NAME prevents anxiety-like and depression-like behaviour in rats exposed to restraint stress

Cited by 85 publications

References 0 publications

Possible Underlying Influence of p38MAPK and NF-κB in the Diminished Anti-anxiety Effect of Diazepam in Stressed Mice

Possible Underlying Influence of p38MAPK and NF-κB in the Diminished Anti-anxiety Effect of Diazepam in Stressed Mice

Exposure to Hypobaric Hypoxia and Reoxygenation Induces Transient Anxiety-Like Behavior in Rat

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